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Associations of blood mitochondrial DNA copy number with social-demographics and cancer risk: results from the Mano-A-Mano Mexican American Cohort.
Zhao, Hua; Chang, David; Ye, Yuanqing; Shen, Jie; Chow, Wong-Ho; Wu, Xifeng.
Afiliação
  • Zhao H; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, 77030 TX, USA.
  • Chang D; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, 77030 TX, USA.
  • Ye Y; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, 77030 TX, USA.
  • Shen J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, 77030 TX, USA.
  • Chow WH; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, 77030 TX, USA.
  • Wu X; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, 77030 TX, USA.
Oncotarget ; 9(39): 25491-25502, 2018 May 22.
Article em En | MEDLINE | ID: mdl-29876003
The relationship between blood mitochondrial DNA (mtDNA) copy number and subsequent cancer risk has been investigated previously. However, such association has never been examined in Mexican Americans. In the current study, we examined association between social-demographic factors and blood mtDNA copy number, as well as longitudinal relationship between cancer and mtDNA copy number, among 10,802 Mexican Americans in the Mano-A-Mano Mexican American Cohort. Overall, mtDNA copy number was statistically significantly higher among participants who developed cancer during the study period than among cancer-free controls (0.17 vs 0.13, P = 0.007). Among cancer-free control participants, mtDNA copy number significantly differed by social-demographic characteristics. However, there was a large degree of heterogeneity in these effects across the mtDNA copy number distribution. In the longitudinal analysis, we observed that higher mtDNA copy number was positively associated with increased risk of all cancer types (adjusted hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.09-1.17). Participants with mtDNA copy number in the fourth (highest) quartile had a higher risk of all cancer (adjusted HR, 2.12; 95% CI, 1.65-2.73) than did participants in the first (lowest) quartile. In summary, our results in Mexican Americans support an association between increased mtDNA copy number and cancer risk. Our results also suggest that mtDNA copy number may be influenced by social and demographic factors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies País/Região como assunto: Mexico Idioma: En Revista: Oncotarget Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies País/Região como assunto: Mexico Idioma: En Revista: Oncotarget Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos