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Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model.
de Barros, Patrícia Aparecida Vieira; Rabelo Andrade, Maria Emília; de Vasconcelos Generoso, Simone; Mendes Miranda, Sued Eustáquio; Dos Reis, Diego Carlos; Lacerda Leocádio, Paola Caroline; de Sales E Souza, Éricka Lorenna; Dos Santos Martins, Flaviano; da Gama, Marco Antonio Sundfeld; Cassali, Geovanni Dantas; Alvarez Leite, Jacqueline Isaura; Antunes Fernandes, Simone Odília; Cardoso, Valbert Nascimento.
Afiliação
  • de Barros PAV; Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Rabelo Andrade ME; Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • de Vasconcelos Generoso S; Department of Nutrition, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Mendes Miranda SE; Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Dos Reis DC; Department of General Pathology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Lacerda Leocádio PC; Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • de Sales E Souza ÉL; Postgraduate Program in Microbiology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Dos Santos Martins F; Postgraduate Program in Microbiology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • da Gama MAS; Embrapa Dairy Cattle, Juiz de Fora, Minas Gerais, Brazil.
  • Cassali GD; Department of General Pathology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Alvarez Leite JI; Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Antunes Fernandes SO; Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Cardoso VN; Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. Electronic address: valbertncardoso@gmail.com.
Biomed Pharmacother ; 103: 1567-1576, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29864944
BACKGROUND: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. OBJECTIVE: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. METHODS: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. RESULTS: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. CONCLUSION: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Linoleicos Conjugados / Mucosite / Fluoruracila / Intestinos Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Linoleicos Conjugados / Mucosite / Fluoruracila / Intestinos Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: França