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FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents.
do Nascimento, Gabrielle Araujo; Leite, Neiva; Furtado-Alle, Lupe; Teixeira, Mayza Dalcin; de Souza, Ricardo Lehtonen Rodrigues; Milano, Gerusa Eisfeld; da Silva, Larissa Rosa; Pizzi, Juliana; Lopes, Wendell Arthur; Lopes, Maria de Fátima Aguiar; Titski, Ana Cláudia Kapp; Tureck, Luciane Viater.
Afiliação
  • do Nascimento GA; Department of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, Brazil.
  • Leite N; Department of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, Brazil.
  • Furtado-Alle L; Department of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, Brazil.
  • Teixeira MD; Department of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, Brazil.
  • de Souza RLR; Department of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, Brazil.
  • Milano GE; Department of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, Brazil.
  • da Silva LR; Department of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, Brazil.
  • Pizzi J; Department of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, Brazil.
  • Lopes WA; Department of Physical Education, State University of Maringa, Av. Colombo 5790, 87020-900 Maringa, PR, Brazil.
  • Lopes MFA; Department of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, Brazil.
  • Titski ACK; Department of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, Brazil.
  • Tureck LV; Department of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, Brazil.
J Obes ; 2018: 3134026, 2018.
Article em En | MEDLINE | ID: mdl-29854435
Purpose: The rs9939609 SNP (T > A) in FTO gene is associated with obesity and type 2 diabetes. The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables. Methods: The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay. Results: The children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (p=0.03) and HOMA (p=0.007) and lower levels of glucose (p=0.003), but the SNP did not modulate the response to physical exercise. Conclusions: In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metabolismo Basal / Exercício Físico / Sobrepeso / Dioxigenase FTO Dependente de alfa-Cetoglutarato / Frequência do Gene / Insulina / Obesidade Tipo de estudo: Prognostic_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Obes Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metabolismo Basal / Exercício Físico / Sobrepeso / Dioxigenase FTO Dependente de alfa-Cetoglutarato / Frequência do Gene / Insulina / Obesidade Tipo de estudo: Prognostic_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Obes Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos