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Detection and phylogenetic characterization of arbovirus dual-infections among persons during a chikungunya fever outbreak, Haiti 2014.
White, Sarah K; Mavian, Carla; Elbadry, Maha A; Beau De Rochars, Valery Madsen; Paisie, Taylor; Telisma, Taina; Salemi, Marco; Lednicky, John A; Morris, J Glenn.
Afiliação
  • White SK; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.
  • Mavian C; Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America.
  • Elbadry MA; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.
  • Beau De Rochars VM; Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
  • Paisie T; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.
  • Telisma T; Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America.
  • Salemi M; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.
  • Lednicky JA; Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America.
  • Morris JG; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.
PLoS Negl Trop Dis ; 12(5): e0006505, 2018 05.
Article em En | MEDLINE | ID: mdl-29851952
In the context of recent arbovirus epidemics, questions about the frequency of simultaneous infection of patients with different arbovirus species have been raised. In 2014, a major Chikungunya virus (CHIKV) epidemic impacted the Caribbean and South America. As part of ongoing screening of schoolchildren presenting with acute undifferentiated febrile illness in rural Haiti, we used RT-PCR to identify CHIKV infections in 82 of 100 children with this diagnosis during May-August 2014. Among these, eight were infected with a second arbovirus: six with Zika virus (ZIKV), one with Dengue virus serotype 2, and one with Mayaro virus (MAYV). These dual infections were only detected following culture of the specimen, suggesting low viral loads of the co-infecting species. Phylogenetic analyses indicated that the ZIKV and MAYV strains differ from those detected later in 2014 and 2015, respectively. Moreover, CHIKV and ZIKV strains from co-infected patients clustered monophyletically in their respective phylogeny, and clock calibration traced back the common ancestor of each clade to an overlapping timeframe of introduction of these arboviruses onto the island.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Arbovirus / Surtos de Doenças / Coinfecção / Febre de Chikungunya Tipo de estudo: Diagnostic_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: Caribe / Haiti Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Arbovirus / Surtos de Doenças / Coinfecção / Febre de Chikungunya Tipo de estudo: Diagnostic_studies Limite: Adolescent / Child / Female / Humans / Male País/Região como assunto: Caribe / Haiti Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos