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Inflammatory and nutritional statuses of patients submitted to resection of gastrointestinal tumors.
Fruchtenicht, Ana Valéria Gonçalves; Poziomyck, Aline Kirjner; Reis, Audrey Machado Dos; Galia, Carlos Roberto; Kabke, Georgia Brum; Moreira, Luis Fernando.
Afiliação
  • Fruchtenicht AVG; Post-Graduation Program in Surgical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Poziomyck AK; Post-Graduation Program in Surgical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Reis AMD; Post-Graduation Program in Surgical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Galia CR; Post-Graduation Program in Surgical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Kabke GB; Post-Graduation Program in Surgical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Moreira LF; Post-Graduation Program in Surgical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Rev Col Bras Cir ; 45(2): e1614, 2018.
Article em Pt, En | MEDLINE | ID: mdl-29846467
OBJECTIVE: to evaluate the association between the nutritional and the inflammatory statuses of patients with cancer of the gastrointestinal tract undergoing surgical resection and to identify predictors of mortality in these patients. METHODS: we conducted a prospective study of 41 patients with gastrointestinal tract cancer submitted to surgery between October 2012 and December 2014. We evaluated the nutritional status by subjective and objective methods. We assessed the inflammatory response and prognosis using the modified Glasgow Prognostic Score (mGPS), Neutrophil/Lymphocyte Ratio (NLR), Onodera Prognostic Nutritional Index (mPNI), Inflammatory-Nutritional Index (INI) and C-Reactive Protein/Albumin ratio (mPINI). RESULTS: half of the patients were malnourished and 27% were at nutritional risk. There was a positive association between the percentage of weight loss (%WL) and the markers NLR (p=0.047), mPINI (p=0.014) and INI (p=0.015). Serum albumin levels (p=0.015), INI (p=0.026) and mPINI (p=0.026) were significantly associated with the PG-SGA categories. On multivariate analysis, albumin was the only inflammatory marker independently related to death (p=0.004). CONCLUSION: inflammatory markers were significantly associated with malnutrition, demonstrating that the higher the inflammatory response, the worse the PG-SGA (B and C) scores and the higher the %WL in these patients. However, further studies aimed at improving surgical outcomes and determining the role of these markers as predictors of mortality are required.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Nutricional / Neoplasias Gastrointestinais Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En / Pt Revista: Rev Col Bras Cir Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estado Nutricional / Neoplasias Gastrointestinais Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En / Pt Revista: Rev Col Bras Cir Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil