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Genetic polymorphism in RANK is associated with mandibular size.
Küchler, Erika Calvano; Nascimento, Mariele Andrade do; Matsumoto, Mirian Aiko Nakane; Romano, Fabio Lourenço; da Silva, Raquel Assed Bezerra; Ayumi Omori, Marjorie; Antunes, Lívia Azeredo; Antunes, Leonardo Santos; da Silva, Léa Assed Bezerra; Nelson-Filho, Paulo.
Afiliação
  • Küchler EC; a Department of Pediatric Dentistry, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
  • Nascimento MAD; a Department of Pediatric Dentistry, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
  • Matsumoto MAN; b Department of Pediatric Dentistry, Orthodontic Clinic, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
  • Romano FL; b Department of Pediatric Dentistry, Orthodontic Clinic, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
  • da Silva RAB; a Department of Pediatric Dentistry, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
  • Ayumi Omori M; a Department of Pediatric Dentistry, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
  • Antunes LA; c Department of Specific Formation, School of Dentistry , Fluminense Federal University , Rio de Janeiro , Brazil.
  • Antunes LS; c Department of Specific Formation, School of Dentistry , Fluminense Federal University , Rio de Janeiro , Brazil.
  • da Silva LAB; a Department of Pediatric Dentistry, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
  • Nelson-Filho P; a Department of Pediatric Dentistry, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.
J Orthod ; 45(3): 157-162, 2018 09.
Article em En | MEDLINE | ID: mdl-29798716
OBJECTIVE: The aim of this study was to evaluate the association between genetic polymorphisms in RANK, RANKL and OPG with maxillary and mandibular dimensions in humans. DESIGN: DNA extracted from saliva and the rs3826620, rs9594738 and rs2073618 polymorphisms in RANK, RANKL and OPG, respectively, were analysed by real-time PCR. Four linear measurements (Co-Gn, GoPg, Co-Go and PTM-A) from lateral cephalograms were examined for the evaluation of craniofacial measurements. ANOVA testing and a multivariate linear regression analysis, adjusted for age and gender, were used for statistical analysis, with an alpha of 5%. Hardy-Weinberg equilibrium was also evaluated using the chi-square test within each polymorphism. SETTING: School of Dentistry of Ribeirão Preto, University of São Paulo. PARTICIPANTS: A total of 100 unrelated non-syndromic Brazilian Caucasian subjects were included in this study. RESULTS: The polymorphism in RANK was associated with a higher Go-Pg measurement (p = .039). In the multivariate analysis, adjusted for age and gender, the polymorphism in RANK was associated with Go-Pg (p = .017) and Co-Gn (p = .043). CONCLUSION: The polymorphism rs3826620 in RANK is associated with the mandibular size.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Osteoprotegerina Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Orthod Assunto da revista: ODONTOLOGIA / ORTODONTIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Osteoprotegerina Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: J Orthod Assunto da revista: ODONTOLOGIA / ORTODONTIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido