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Short-segment transverse myelitis lesions in a cohort of Latin American patients with neuromyelitis optica spectrum disorders.
Carnero Contentti, Edgar; Daccach Marques, Vanessa; Soto de Castillo, Ibis; Tkachuk, Verónica; Antunes Barreira, Amilton; Armas, Elizabeth; Chiganer, Edson; de Aquino Cruz, Camila; Di Pace, José Luis; Hryb, Javier Pablo; Lavigne Moreira, Carolina; Lessa, Carmen; Molina, Omaira; Perassolo, Mónica; Soto, Arnoldo; Caride, Alejandro.
Afiliação
  • Carnero Contentti E; Neuroimmunology Unit, Department of Neuroscience Hospital Alemán, Buenos Aires, Argentina. junior.carnero@hotmail.com.
  • Daccach Marques V; Departamento de Neurociências e Ciências do Comportamento, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Sao Pablo, Brazil.
  • Soto de Castillo I; Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela.
  • Tkachuk V; Neurology Department, Hospital José de San Martin, Buenos Aires, Argentina.
  • Antunes Barreira A; Departamento de Neurociências e Ciências do Comportamento, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Sao Pablo, Brazil.
  • Armas E; Neurology Department, Hospital Universitario de Caracas, Caracas, Venezuela.
  • Chiganer E; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
  • de Aquino Cruz C; Departamento de Neurociências e Ciências do Comportamento, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Sao Pablo, Brazil.
  • Di Pace JL; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
  • Hryb JP; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
  • Lavigne Moreira C; Departamento de Neurociências e Ciências do Comportamento, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Sao Pablo, Brazil.
  • Lessa C; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
  • Molina O; Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela.
  • Perassolo M; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
  • Soto A; Neurology Department, Hospital Universitario de Caracas, Caracas, Venezuela.
  • Caride A; Neuroimmunology Unit, Department of Neuroscience Hospital Alemán, Buenos Aires, Argentina.
Spinal Cord ; 56(10): 949-954, 2018 Oct.
Article em En | MEDLINE | ID: mdl-29789706
STUDY DESIGN: Multicenter retrospective study. OBJECTIVES: The aim was to determine the frequency and magnetic resonance imaging (MRI) features of short-segment transverse myelitis (STM) in patients with neuromyelitis optica spectrum disorders (NMOSD) during a myelitis attack. SETTING: Latin American diagnostic centres (Neuroimmunology Unit). A multicenter study from Argentina, Brazil and Venezuela was performed. METHODS: Seventy-six patients with NMOSD were included. We analyzed 346 attacks and reviewed spinal cord MRIs performed within 30 days from spinal attack onset. Sagittal and axial characteristics on cervical and thoracic MRI (1.5 tesla) were observed. Demographics, clinical, serological, and disability data were collected. RESULTS: Among the 76 patients with NMOSD, isolated STM was observed in 8% (n = 6), multisegmental lesions (longitudinally extensive transverse myelitis (LETM) + STM) in 28% (n = 21; 13 had at least one STM), LETM in 42% (n = 32), and normal spinal MRI in 22% (n = 17). However, isolated STM was increased by 10% in patients with NMOSD with spinal lesions (6 out of 59) with mean attacks of 2.5 (±0.83) and last follow-up expanded disability status scale (EDSS) of 3.1 (±2.63). Positive aquaporin 4 antibodies (AQP4-ab) were found in 50%. Upper-cervical lesion was most frequently observed (5 out of 6). Myelitis was preceded by ON in all isolated patients with STM. Only one had a positive gadolinium lesion and none of these had asymptomatic spinal cord lesion. CONCLUSION: Isolated STM does not exclude NMOSD diagnosis. Therefore, APQ4-ab testing could be useful during a myelitis attack with STM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Espinal / Neuromielite Óptica Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Spinal Cord Assunto da revista: NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Espinal / Neuromielite Óptica Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Spinal Cord Assunto da revista: NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido