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The antidepressant-like effect of galanin in the dorsal raphe nucleus of rats involves GAL2 receptors.
de Souza, Mayara Machado; Silote, Gabriela Pandini; Herbst, Leticia Santos; Funck, Vinicius Rafael; Joca, Samia Regiane Lourenço; Beijamini, Vanessa.
Afiliação
  • de Souza MM; Department of Pharmaceutical Sciences, Health Science Centre, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil.
  • Silote GP; Department of Physics and Chemistry, School of Pharmaceutical Sciences, University of São Paulo, Ribeirão Preto, SP, Brazil; Biochemistry and Pharmacology Postgraduate Program, Health Science Center, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil.
  • Herbst LS; Department of Pharmaceutical Sciences, Health Science Centre, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil.
  • Funck VR; Biochemistry and Pharmacology Postgraduate Program, Health Science Center, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil.
  • Joca SRL; Department of Physics and Chemistry, School of Pharmaceutical Sciences, University of São Paulo, Ribeirão Preto, SP, Brazil; Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Denmark.
  • Beijamini V; Department of Pharmaceutical Sciences, Health Science Centre, Federal University of Espirito Santo, Vitoria, ES, 29043-900, Brazil. Electronic address: vanessa.harres@ufes.br.
Neurosci Lett ; 681: 26-30, 2018 08 10.
Article em En | MEDLINE | ID: mdl-29787787
Galanin is a neuropeptide distributed in human and rat brain regions that are involved with emotional regulation, such as the dorsal raphe nucleus (DRN). Galanin effects in the DRN are mediated by GAL1 and GAL2 receptors. Intracerebral infusion of a GAL2 (AR-M1896) or a GAL1 (M617) agonist induced either antidepressant or depressive-like effect, respectively, in rats exposed to the forced swimming test (FST). However, it is not clear if GAL1 and/or GAL2 receptors present in the DRN would be involved in such effects. Therefore, we investigated the effects induced by intra-DRN infusion of galanin (0.3 nmol), AR-M1896 (1 nmol, GAL2 agonist), or M617 (GAL1 agonist) in rats exposed to the FST. Galanin and AR-M1896 intra-DRN administration induced antidepressant-like effect in the FST. However, M617 did not induce any change in the FST. Neither M617 nor AR-M1896 changed the locomotor activity of rats in the open field test. Intra-DRN pre-treatment with M871 (1 nmol), a selective GAL2 antagonist, counteracted the antidepressant-like effect induced by galanin. These results suggest that galanin signaling through GAL2 receptors in the DRN produces triggers antidepressant-like effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Precursores de Proteínas / Galanina / Receptor Tipo 2 de Galanina / Depressão / Núcleo Dorsal da Rafe / Antidepressivos Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Precursores de Proteínas / Galanina / Receptor Tipo 2 de Galanina / Depressão / Núcleo Dorsal da Rafe / Antidepressivos Limite: Animals Idioma: En Revista: Neurosci Lett Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda