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Bone repair with raloxifene and bioglass nanoceramic composite in animal experiment.
Lisboa-Filho, Paulo N; Gomes-Ferreira, Pedro Henrique S; Batista, Fábio R S; Momesso, Gustavo A C; Faverani, Leonardo P; Okamoto, Roberta.
Afiliação
  • Lisboa-Filho PN; a Department of Physics , UNESP - São Paulo State University, School of Sciences , Bauru , SP , Brazil.
  • Gomes-Ferreira PHS; b Department of Surgery and Integrated Clinic , UNESP - São Paulo State University, Araçatuba Dental School , Araçatuba , SP , Brazil.
  • Batista FRS; b Department of Surgery and Integrated Clinic , UNESP - São Paulo State University, Araçatuba Dental School , Araçatuba , SP , Brazil.
  • Momesso GAC; b Department of Surgery and Integrated Clinic , UNESP - São Paulo State University, Araçatuba Dental School , Araçatuba , SP , Brazil.
  • Faverani LP; b Department of Surgery and Integrated Clinic , UNESP - São Paulo State University, Araçatuba Dental School , Araçatuba , SP , Brazil.
  • Okamoto R; c Department of Basic Sciences UNESP - São Paulo State University, School of Sciences , Bauru , SP , Brazil.
Connect Tissue Res ; 59(sup1): 97-101, 2018 12.
Article em En | MEDLINE | ID: mdl-29745810
OBJECTIVE: This study proposes to evaluate, by means of microtomographic analysis, the topical potential of raloxifene combined with BioGran® through the sonochemical method in the repair of critical bone defects in the calvaria of rats. The hypothesis was that the homogenization of Raloxifene to Biogran at the 20% concentration would improve the bone repair at the grafted site. MATERIALS AND METHODS: A 5-mm calvaria bone defect was induced in three groups: CTR (100% BioGran®); RAL10 (90% BioGran® and 10% raloxifene), and RAL20 (80% BioGran® and 20% raloxifene). The animals were euthanized after 30 days and the microCT analysis was then performed to evaluate the parameters bone volume (BV), bone volume percentage (BV/TV), trabecular bone thickness (Tb.Th), and the separation and number of trabeculae (Tb.Sp and Tb.N). The obtained results were compared using ANOVA and Tukey test (p < 0.05). RESULTS: The best results were found for the CTR and RAL20 groups, in which the BV, BV/TV, Tb.Sp, and Tb.N parameters were statistically significant in comparison with RAL10 (p < 0.05). CONCLUSIONS: In view of the results obtained in this experiment, we can conclude that BioGran® alone or in an 80/20 mass concentration with raloxifene can lead to favorable bone formation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Crânio / Regeneração Óssea / Densidade Óssea / Cerâmica / Cloridrato de Raloxifeno / Nanocompostos Limite: Animals Idioma: En Revista: Connect Tissue Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Crânio / Regeneração Óssea / Densidade Óssea / Cerâmica / Cloridrato de Raloxifeno / Nanocompostos Limite: Animals Idioma: En Revista: Connect Tissue Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido