Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF-α and IL-6) and the expression of COX-2.
Phytother Res
; 32(9): 1750-1754, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-29726034
The flavonoids comprise a large class of plant metabolites distributed in food plants. These compounds have antioxidant, antitumor, antiallergic, and antiinflammatory effects. The molecular mechanisms of their biological activities remain to be clearly understood. We investigated the in vitro antiinflammatory potential of a flavonoid mixture and isolated compounds from the leaves of Boldoa purpurascens. Our results provide direct evidence of the antiinflammatory effects of the mixture, which are mediated by the inhibition of the proinflammatory cytokines tumor necrosis factor α and interleukin 6 as well as the modulation of the expression of cyclooxygenase 2.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Inibidores de Ciclo-Oxigenase
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Nyctaginaceae
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Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Phytother Res
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Reino Unido