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Macrophage migration inhibitory factor as an incriminating agent in vitiligo.
Farag, Azza Gaber Antar; Hammam, Mostafa Ahmed; Habib, Mona SalahEldeen; Elnaidany, Nada Farag; Kamh, Mona Eaid.
Afiliação
  • Farag AGA; Dermatology, Andrology and STDs department, Faculty of Medicine, Menoufia University, El Menoufia, Egypt.
  • Hammam MA; Dermatology, Andrology and STDs department, Faculty of Medicine, Menoufia University, El Menoufia, Egypt.
  • Habib MS; Medical Biochemistry department, Faculty of Medicine, Menoufia University, El Menoufia, Egypt.
  • Elnaidany NF; Clinical Pharmacy department, Faculty of Pharmacy, MSA University, 6th October City, Egypt.
  • Kamh ME; Dermatology, Andrology and STDs department, Faculty of Medicine, Menoufia University, El Menoufia, Egypt.
An Bras Dermatol ; 93(2): 191-196, 2018 03.
Article em En | MEDLINE | ID: mdl-29723363
BACKGROUND: Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms and, lately, there has been more emphasis on autoinflammatory mediators. Among these is the macrophage migration inhibitory factor, which is involved in many autoimmune skin diseases. However, little is known about the contribution of this factor to vitiligo vulgaris. OBJECTIVE: To determine the hypothesized role of migration inhibitory factor in vitiligo via estimation of serum migration inhibitory factor levels and migration inhibitory factor mRNA concentrations in patients with vitiligo compared with healthy controls. We also aimed to assess whether there is a relationship between the values of serum migration inhibitory factor and/or migration inhibitory factor mRNA with disease duration, clinical type and severity in vitiligo patients. METHODS: Evaluation of migration inhibitory factor serum level and migration inhibitory factor mRNA expression by ELISA and real-time PCR, respectively, were performed for 50 patients with different degrees of vitiligo severity and compared to 15 age- and gender-matched healthy volunteers as controls. RESULTS: There was a highly significant increase in serum migration inhibitory factor and migration inhibitory factor mRNA levels in vitiligo cases when compared to controls (p<0.001). There was a significant positive correlation between both serum migration inhibitory factor and migration inhibitory factor mRNA concentrations in vitiligo patients, and each of them with duration and severity of vitiligo. In addition, patients with generalized vitiligo have significantly elevated serum migration inhibitory factor and mRNA levels than control subjects. STUDY LIMITATIONS: Small number of investigated subjects. CONCLUSIONS: Migration inhibitory factor may have an active role in the development of vitiligo, and it may also be a useful index of disease severity. Consequently, migration inhibitory factor may be a new treatment target for vitiligo patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitiligo / RNA Mensageiro / Fatores Inibidores da Migração de Macrófagos Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: An Bras Dermatol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Egito País de publicação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitiligo / RNA Mensageiro / Fatores Inibidores da Migração de Macrófagos Tipo de estudo: Observational_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: An Bras Dermatol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Egito País de publicação: Espanha