Blocking or enhancing effects of some basic emollients in UVA penetration.
An Bras Dermatol
; 93(2): 238-241, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29723354
BACKGROUND: Topical agents used in combination with phototherapy or photochemotherapy may have both blocking or enhancing effects in ultraviolet rays. OBJECTIVE: In this in vivo study, the effects of topical petrolatum, basis cream, glycerine, and olive oil on the transmission of ultraviolet A radiation were investigated. METHODS: A test was performed to determine the minimal phototoxic dose on 29 volunteers with only psoralen plus ultraviolet A (PUVA) and then the same test was repeated with white petrolatum, basis cream, glycerine, olive oil, and sunscreen (0.3cc/25cm2). The effects of each agent on the minimal phototoxic dose were determined after 72 h. RESULTS: When compared to pure PUVA, there was a statistically significant increase in the mean minimal phototoxic dose values by the application of white petrolatum (P = 0.011), but there was no significant increase or decrease in the mean minimal phototoxic dose values after the application of basis cream (P = 0.326), glycerine (P = 0.611) or olive oil (P = 0.799). STUDY LIMITATIONS: Low number of patients Conclusion: The application of white petrolatum, which has a blocking effect, and also of basis cream immediately before PUVA therapy should not be recommended. Although we specify that glycerine and maybe olive oil can be used before photochemotherapy, there is a need for further research in larger series.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vaselina
/
Fotoquimioterapia
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Terapia PUVA
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Dermatopatias
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Raios Ultravioleta
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Fármacos Fotossensibilizantes
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Emolientes
Tipo de estudo:
Clinical_trials
/
Evaluation_studies
Limite:
Humans
Idioma:
En
Revista:
An Bras Dermatol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Turquia
País de publicação:
Espanha