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Genomic Instability in Buccal Mucosal Cells of Municipal Street Sweepers as Evaluated by Micronucleus Test.
DA Silva, Victor Hugo Pereira; Andrade, Mariana Carvalho; Claudio, Samuel Rangel; Yujra, Veronica Quispe; Alpire, Maria Esther Suarez; Dos Santos, Jean Nunes; Cury, Patricia Ramos; Ribeiro, Daniel Araki.
Afiliação
  • DA Silva VHP; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Santos, Brazil.
  • Andrade MC; Post-graduate Program in Dentistry and Health, Federal University of Bahia, UFBA, Salvador, Brazil.
  • Claudio SR; Department of Pathology, Paulista Medical School, UNIFESP, Santos, Brazil.
  • Yujra VQ; Department of Pathology, Paulista Medical School, UNIFESP, Santos, Brazil.
  • Alpire MES; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Santos, Brazil.
  • Dos Santos JN; Post-graduate Program in Dentistry and Health, Federal University of Bahia, UFBA, Salvador, Brazil.
  • Cury PR; Post-graduate Program in Dentistry and Health, Federal University of Bahia, UFBA, Salvador, Brazil.
  • Ribeiro DA; Department of Biosciences, Federal University of Sao Paulo, UNIFESP, Santos, Brazil daribeiro@unifesp.br.
Anticancer Res ; 38(5): 3123-3126, 2018 05.
Article em En | MEDLINE | ID: mdl-29715151
BACKGROUND/AIM: Since street sweepers comprises a group of workers who are in daily contact with rubbish, dust and air pollution, the aim of this study was to evaluate potential cytotoxic and mutagenic effects in buccal mucosa cells of street sweepers. MATERIALS AND METHODS: A total of 20 male street sweepers aged from 22 to 56 years were included in the experimental group. A total of 20 men matched by age were used as the control group. Cytotoxicity and mutagenicity were analyzed by micronucleus test in buccal mucosal cells. RESULTS: Statistically significant differences (p<0.05) in the frequency of micronuclei was detected in the street sweepers when compared to the control group. No remarkable differences were found to other metanuclear alterations indicative for cytotoxicity such as pyknosis, karyolysis, and karryorhexis when compared to matched controls. CONCLUSION: Taken together, our results indicate that street sweepers comprise an at-risk group as a result of increased mutagenicity found to buccal mucosa cells.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exposição Ocupacional / Poluição do Ar / Mucosa Bucal Limite: Adult / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Anticancer Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Grécia
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exposição Ocupacional / Poluição do Ar / Mucosa Bucal Limite: Adult / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Anticancer Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Grécia