Your browser doesn't support javascript.
loading
Anti-arthritic properties of crude extract from Chenopodium ambrosioides L. leaves.
Pereira, Wanderson S; da Silva, Girlaine P; Vigliano, Mariana V; Leal, Nathalia R F; Pinto, Fabiana A; Fernandes, Daniele C; Santos, Shirley V M; Martino, Thiago; Nascimento, Johnny R; de Azevedo, Ana Paula S; Fonseca, Eduardo N; Velozo, Leosvaldo S M; Souza Neto, Lauro R; Bastos, Frederico F; Portari, Elyzabeth A; Sabino, Kátia C Carvalho; Nascimento, Flávia; Coelho, Marsen G P.
Afiliação
  • Pereira WS; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • da Silva GP; Laboratory of Immunophysiology, Department of Pathology, Center for Biological Sciences and Health, Federal University of Maranhão, São Luís, Maranhão, Brazil.
  • Vigliano MV; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Leal NRF; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Pinto FA; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Fernandes DC; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Santos SVM; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Martino T; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Nascimento JR; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • de Azevedo APS; Laboratory of Immunophysiology, Department of Pathology, Center for Biological Sciences and Health, Federal University of Maranhão, São Luís, Maranhão, Brazil.
  • Fonseca EN; Laboratory of Immunophysiology, Department of Pathology, Center for Biological Sciences and Health, Federal University of Maranhão, São Luís, Maranhão, Brazil.
  • Velozo LSM; Department of Plant Biology, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Souza Neto LR; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Bastos FF; Laboratory of Biochemical Toxicology, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Portari EA; Laboratory of Biochemical Toxicology, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Sabino KCC; Department of Pathology and Laboratories, Pathological Anatomy, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Nascimento F; Laboratory of Applied Immunology and Biochemistry of Proteins and Natural Products, Department of Biochemistry, Biomedical Center, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Coelho MGP; Laboratory of Immunophysiology, Department of Pathology, Center for Biological Sciences and Health, Federal University of Maranhão, São Luís, Maranhão, Brazil.
J Pharm Pharmacol ; 70(8): 1078-1091, 2018 Aug.
Article em En | MEDLINE | ID: mdl-29708588
OBJECTIVES: To evaluate the effect of hydroalcoholic crude extract (HCE) from Chenopodium ambrosioides leaves on the development of type II collagen-induced arthritis (CIA) and on pro-inflammatory cytokine balance. METHODS: Collagen-induced arthritis was induced in DBA1/J mice. On the 21st day, the mice were treated orally with HCE or methotrexate, daily. Six weeks after beginning the treatment, the following measures were determined: lymphoid organs cell numbers, percentage of blood cells, IL-6, IFN-γ, TNF-α and IL-17 serum concentrations, activity of hepatic and kidney glutathione S-transferase, hepatic 7-ethoxyresorufin-O-deethylase activity, bone density and histopathology. KEY FINDINGS: Treatment of CIA mice with HCE 5 mg/kg (HCE5) reduced the percentage of neutrophils and macrophages and the number of bone marrow cells and increased the lymphocyte numbers and the inguinal lymph node cellularity. This treatment inhibited the serum concentration of IL-6 and TNF-α, which may be related to the preservation of bone density and to the slight thickening of periarticular tissues, with minimal fibrosis and fibroblast proliferation in the joints. The CIA group presented advanced articular erosion and synovial hyperplasia. Phytochemical analysis showed mainly flavonols. CONCLUSIONS: HCE5 presented anti-arthritic potential and reduced IL-6 and TNF-α, which participate directly in the development and maintenance of the inflammatory process in rheumatoid arthritis.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Extratos Vegetais / Folhas de Planta / Chenopodium ambrosioides / Anti-Inflamatórios Limite: Animals Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Extratos Vegetais / Folhas de Planta / Chenopodium ambrosioides / Anti-Inflamatórios Limite: Animals Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido