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Association between interleukin-6, C-reactive protein and adiponectin with adiposity: Findings from the 1993 pelotas (Brazil) birth cohort at 18 and 22 years.
Menezes, Ana Maria Baptista; Oliveira, Paula Duarte; Wehrmeister, Fernando César; Gonçalves, Helen; Assunção, Maria Cecilia F; Tovo-Rodrigues, Luciana; Ferreira, Gustavo Dias; Oliveira, Isabel O.
Afiliação
  • Menezes AMB; Federal University of Pelotas - Postgraduate Program in Epidemiology, Rua Marechal Deodoro, 1160, 3° andar, Pelotas, RS. Zip code: 96020-220, Brazil. Electronic address: anamene.epi@gmail.com.
  • Oliveira PD; Federal University of Pelotas - Postgraduate Program in Epidemiology, Rua Marechal Deodoro, 1160, 3° andar, Pelotas, RS. Zip code: 96020-220, Brazil. Electronic address: pauladuartedeoliveira@gmail.com.
  • Wehrmeister FC; Federal University of Pelotas - Postgraduate Program in Epidemiology, Rua Marechal Deodoro, 1160, 3° andar, Pelotas, RS. Zip code: 96020-220, Brazil. Electronic address: fcwehrmeister@gmail.com.
  • Gonçalves H; Federal University of Pelotas - Postgraduate Program in Epidemiology, Rua Marechal Deodoro, 1160, 3° andar, Pelotas, RS. Zip code: 96020-220, Brazil. Electronic address: hdgs.epi@gmail.com.
  • Assunção MCF; Federal University of Pelotas - Postgraduate Program in Epidemiology, Rua Marechal Deodoro, 1160, 3° andar, Pelotas, RS. Zip code: 96020-220, Brazil. Electronic address: cecilia.epi@gmail.com.
  • Tovo-Rodrigues L; Federal University of Pelotas - Postgraduate Program in Epidemiology, Rua Marechal Deodoro, 1160, 3° andar, Pelotas, RS. Zip code: 96020-220, Brazil. Electronic address: luciana.tovo@gmail.com.
  • Ferreira GD; Federal University of Pelotas, Department of Physiology and Pharmacology Campus Capão do Leão, s/n. Pelotas, RS. Zip code: 96010-900, Brazil. Electronic address: gusdiasferreira@gmail.com.
  • Oliveira IO; Federal University of Pelotas - Postgraduate Program in Epidemiology, Rua Marechal Deodoro, 1160, 3° andar, Pelotas, RS. Zip code: 96020-220, Brazil. Electronic address: isabel.ufpel@gmail.com.
Cytokine ; 110: 44-51, 2018 10.
Article em En | MEDLINE | ID: mdl-29704817
BACKGROUND: Most of the literature has shown a direct association between adiposity, interleukin-6 (IL-6) and C-reactive protein (CRP), and an inverse association with adiponectin. The aim of this paper was to assess the association of obesity measurements and IL-6, CRP and adiponectin. METHODS: We performed cross-sectional/longitudinal analysis in the 1993 Birth Cohort in Brazil. Associations between IL-6 (pg/mL), CRP (mg/L) and adiponectin (µg/Ml) with body mass index (BMI), waist circumference (WC), percentage total fat mass (FM) (BODPOD) and trunk FM (DXA) were verified. Four trajectory variables were generated: (a) highest tertile/obesity according to BMI in both follow-ups; (b) highest tertile/obesity only at 18 years; (c) highest tertile/obesity only at 22 years; (d) not in the highest tertile/not obese at both ages. RESULTS: We found a direct association for IL-6 and CRP and an inverse association for adiponectin with measures of adiposity. For instance, for females, the highest mean IL-6 and CRP, respectively, was for those who had been in the obese category at 18-22 years (2.49; 3.75), in the highest tertile of WC (2.11; 3.08), in the highest % of FM (1.56; 3.30 l), and in the highest tertile of trunk FM (2.07; 3.26) (p < 0.001 for all these results in the adjusted analysis). Adiponectin showed an inverse association for the above variables, with lower mean values for males than females. CONCLUSION: There was a longitudinal and direct association between adiposity and IL-6 and CRP, and an inverse association with adiponectin at 22 years.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Interleucina-6 / Adiponectina / Adiposidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Interleucina-6 / Adiponectina / Adiposidade Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Cytokine Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido