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Early frailty transition predicts 15-year mortality among nondisabled older Mexican Americans.
Li, Chih-Ying; Al Snih, Soham; Karmarkar, Amol; Markides, Kyriakos S; Ottenbacher, Kenneth J.
Afiliação
  • Li CY; Division of Rehabilitation Sciences, School of Health Professions, University of Texas Medical Branch (UTMB), Galveston, USA.
  • Al Snih S; Division of Rehabilitation Sciences, School of Health Professions, University of Texas Medical Branch (UTMB), Galveston, USA; Division of Geriatrics, Department of Internal Medicine, UTMB, Galveston, USA.
  • Karmarkar A; Division of Rehabilitation Sciences, School of Health Professions, University of Texas Medical Branch (UTMB), Galveston, USA.
  • Markides KS; Department of Preventive Medicine and Community Health, UTMB, Galveston, USA.
  • Ottenbacher KJ; Division of Rehabilitation Sciences, School of Health Professions, University of Texas Medical Branch (UTMB), Galveston, USA. Electronic address: kottenba@utmb.edu.
Ann Epidemiol ; 28(6): 362-367.e3, 2018 06.
Article em En | MEDLINE | ID: mdl-29703521
PURPOSE: To investigate the effect of early frailty transitions on 15-year mortality risk. METHODS: Longitudinal data analysis of the Hispanic Established Populations for the Epidemiological Study of the Elderly involving 1171 community-dwelling Mexican Americans aged ≥67 years and older. Frailty was determined using the modified frailty phenotype, including unintentional weight loss, weakness, self-reported exhaustion, and slow walking speed. Participants were defined at baseline as nonfrail, prefrail, or frail and divided into nine transition groups, during a 3-year observation period. RESULTS: Mean age was 77.0 years (standard deviation [SD] = 5.3) and 59.1% were female. Participants who transitioned from prefrail to frail (hazard ratio [HR] = 1.68, 95% confidence interval [CI] = 1.23-2.28), frail to prefrail (HR = 1.54, 95% CI = 1.05-2.28); or who remained frail (HR = 1.72, 95% CI = 1.21-2.44), had significant higher 15-year mortality risk than those who remained nonfrail. Participants transitioning from frail to nonfrail had a similar 15-year mortality risk as those who remained nonfrail (HR = 0.96, 95% CI = 0.53-1.72). Weight loss and slow walking speed were associated with transitions to frailty. CONCLUSIONS: An early transition from frail to nonfrail in older Mexican Americans was associated with a 4% decrease in mortality compared with those who remained nonfrail, although this difference was not statistically significant. Additional longitudinal research is needed to understand positive transitions in frailty.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Avaliação Geriátrica / Mortalidade / Idoso Fragilizado / Americanos Mexicanos / Vida Independente / Fragilidade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do norte / Mexico Idioma: En Revista: Ann Epidemiol Assunto da revista: EPIDEMIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Avaliação Geriátrica / Mortalidade / Idoso Fragilizado / Americanos Mexicanos / Vida Independente / Fragilidade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male País/Região como assunto: America do norte / Mexico Idioma: En Revista: Ann Epidemiol Assunto da revista: EPIDEMIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos