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Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis.
Dias, Alyria Teixeira; de Castro, Sandra Bertelli Ribeiro; de Souza Alves, Caio César; Evangelista, Marcilene Gomes; da Silva, Luan Cristian; Reis, Daniele Ribeiro de Lima; Machado, Marco Antonio; Juliano, Maria Aparecida; Ferreira, Ana Paula.
Afiliação
  • Dias AT; IMUNOCET, Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
  • de Castro SBR; Department of Pharmacy, Federal University of Juiz de Fora, Governador Valadares, Brazil.
  • de Souza Alves CC; Faculty of Medicine, Federal University of the Valleys of Jequitinhonha and Mucuri, Teófilo Otoni, Brazil.
  • Evangelista MG; IMUNOCET, Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
  • da Silva LC; IMUNOCET, Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
  • Reis DRL; Empresa Brasileira de Pesquisa Agropecuária, Juiz de Fora, Brazil.
  • Machado MA; Empresa Brasileira de Pesquisa Agropecuária, Juiz de Fora, Brazil.
  • Juliano MA; Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.
  • Ferreira AP; IMUNOCET, Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, 36036-900, Brazil. ana.paula@ufjf.edu.br.
Inflamm Res ; 67(7): 597-608, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29687146
OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein). TREATMENT: Genistein was used at a dose of 200 mg/kg s.c. and were initiated 2 days before the immunization and continued daily until day 6 postimmunization. METHODS: Animals were monitored daily for clinical signs of EAE up to day 21. Inflammatory infiltration, demyelination, Toll-like receptor (TLR) expression, cytokines and transcription factors were analyzed in spinal cords. RESULTS: The present study demonstrates, for the first time, the genistein ability to modulate the factors involved in the innate immune response in the early stages of EAE. The genistein therapy delayed the onset of the disease, with reduced inflammatory infiltration and demyelination. In addition, the expression of TLR3, TLR9 and IFN-ß were increased in genistein group, with reduction in the factors of TH1 and Th17 cells. CONCLUSION: These findings shed light on the potential of genistein as a prophylactic strategy for multiple sclerosis (MS) prevention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genisteína / Encefalomielite Autoimune Experimental / Receptores Toll-Like / Fatores Imunológicos Limite: Animals Idioma: En Revista: Inflamm Res Assunto da revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genisteína / Encefalomielite Autoimune Experimental / Receptores Toll-Like / Fatores Imunológicos Limite: Animals Idioma: En Revista: Inflamm Res Assunto da revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça