Your browser doesn't support javascript.
loading
Prognostic value of Ki-67 according to age in patients with triple-negative breast cancer.
Zenzola, V; Cabezas-Quintario, M A; Arguelles, M; Pérez-Fernández, E; Izarzugaza, Y; Correa, A; García-Foncillas, J.
Afiliação
  • Zenzola V; Oncology Department, Hospital Fundación Jiménez Díaz, Madrid, Spain.
  • Cabezas-Quintario MA; Pathology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain. mariancabezas@hotmail.com.
  • Arguelles M; Pathology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
  • Pérez-Fernández E; Research Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
  • Izarzugaza Y; Oncology Department, Hospital Fundación Jiménez Díaz, Madrid, Spain.
  • Correa A; Oncology Department, Hospital Fundación Jiménez Díaz, Madrid, Spain.
  • García-Foncillas J; Oncology Department, Hospital Fundación Jiménez Díaz, Madrid, Spain.
Clin Transl Oncol ; 20(11): 1448-1454, 2018 Nov.
Article em En | MEDLINE | ID: mdl-29671222
PURPOSE: The prognostic value of Ki-67 in triple-negative breast cancer (TNBC) is yet unclear because the cut-off points employed differ widely and its predictive effect may vary according to age. The purpose of this study was to analyze the role of Ki-67 among patients with TNBC, and determine the optimal Ki-67 cut-off point to demonstrate its prognostic relevance associated with patient age and treatment strategy. METHODS/PATIENTS: 201 consecutive patients treated for primary TNBC from 1999 to 2014 were analyzed. Clinicopathological characteristics and outcomes were compared between patients treated with neoadjuvant or adjuvant chemotherapy. We used time-dependent receiver operating characteristic (ROC) curve and time-dependent area under the ROC curve (AUC) to evaluate the discriminative ability of Ki-67 at 3 and 5 years of follow-up. A Ki-67 cut-off point that maximized sensibility and specificity was established. Interaction effect between age and Ki-67 on disease-free survival (DFS) and overall survival (OS) was evaluated by stratified analysis. RESULTS: According to the coordinates of the ROC curves, the best cut-off point for Ki-67 was 60% (high/low). In the whole group, there was not a statistically significant association between Ki-67 and OS and DFS, using a cut-off point of 60%. In multivariate analysis (COX proportional hazards regression), for DFS high Ki-67 (> 60%) was a poor prognostic factor in patients > 40 years old and a better prognostic factor among the patients < 40 years old. CONCLUSION: Prognostic value of Ki-67 in TNBC, using a cut-off point of 60%, may vary depending on age.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Biomarcadores Tumorais / Antígeno Ki-67 / Neoplasias de Mama Triplo Negativas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Biomarcadores Tumorais / Antígeno Ki-67 / Neoplasias de Mama Triplo Negativas Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália