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Adherence and immune response to revaccination following hematopoietic stem cell transplantation at a pediatric onco-hematology reference center.
Gouveia-Alves, Fernanda; Gouveia, Roseane; Ginani, Valéria C; Seber, Adriana; Kuramoto, Danielle A; Murad, Gabriel F A; Spina, Fernanda G; Petrilli, Antonio S; Zecchin, Victor G; Granato, Celso; Carlesse, Fabianne; de Moraes-Pinto, Maria Isabel.
Afiliação
  • Gouveia-Alves F; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Gouveia R; Hospital Samaritano, São Paulo, Brazil.
  • Ginani VC; Hospital Samaritano, São Paulo, Brazil.
  • Seber A; Hospital Samaritano, São Paulo, Brazil.
  • Kuramoto DA; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Murad GFA; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Spina FG; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Petrilli AS; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Zecchin VG; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Granato C; Department of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Carlesse F; Fleury Group, São Paulo, Brazil.
  • de Moraes-Pinto MI; Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
Transpl Infect Dis ; 20(4): e12903, 2018 Aug.
Article em En | MEDLINE | ID: mdl-29668078
BACKGROUND: Revaccination after hematopoietic stem cell transplantation (HSCT) is necessary to compensate for the loss of immunological memory. The aims of this study were to evaluate the adherence to revaccination schedule and the humoral immune response to different vaccine antigens in HSCT pediatric and young adult patients. METHODS: Patients submitted to HSCT for over 3 years were recruited. After written informed consent, a questionnaire was filled in, the vaccination card was analyzed, a blood sample was collected and tested by ELISA for diphtheria, Haemophilus influenzae type b (Hib), hepatitis A, hepatitis B, tetanus, measles, rubella, and varicella antibodies. RESULTS: Sixty-three patients (mean age at HSCT, 10.7 years) were evaluated. Forty-one (65%) were male; 34 (54%) had allogeneic and 29 (46%), autologous HSCT. Complete adherence to diphtheria revaccination was found in 79.4% patients and seropositivity was found in 92% of those who completed the revaccination schedule; for Hib, 68.3% adherence and 95.3% seropositivity were observed; for hepatitis A, 63.5% adherence and 92.5% seropositivity; for 3 doses of hepatitis B, 86.8% adherence and 79.2% seropositivity; for tetanus, 79.4% adherence and 100% seropositivity; for measles and rubella, 17.5% adherence and 100% seropositivity; for varicella, 7.9% adherence and 100% seropositivity. The existence of a Vaccination Center for Special Immunobiologicals in patients' municipality was positively associated with completed vaccine schedule; on the other hand, chronic GVHD was negatively associated with revaccination adherence. CONCLUSION: Hematopoietic stem cell transplantation patients showed good seropositivity rates after complete vaccination schedule. However, a low coverage rate was observed for live attenuated antigens.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunização Secundária / Cooperação do Paciente / Vacinação / Hospedeiro Imunocomprometido / Transplante de Células-Tronco Hematopoéticas Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Transpl Infect Dis Assunto da revista: TRANSPLANTE Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunização Secundária / Cooperação do Paciente / Vacinação / Hospedeiro Imunocomprometido / Transplante de Células-Tronco Hematopoéticas Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Transpl Infect Dis Assunto da revista: TRANSPLANTE Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Dinamarca