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The rs1256031 of estrogen receptor ß gene is associated with type 2 diabetes.
Herrera-Lopez, Ema E; Castelan-Martinez, Osvaldo D; Suarez-Sanchez, Fernando; Gomez-Zamudio, Jaime H; Peralta-Romero, Jose J; Cruz, Miguel; Valladares-Salgado, Adan.
Afiliação
  • Herrera-Lopez EE; Unidad de Investigacion Medica en Bioquimica, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Castelan-Martinez OD; Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Suarez-Sanchez F; Unidad de Investigacion Medica en Bioquimica, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Gomez-Zamudio JH; Unidad de Investigacion Medica en Bioquimica, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Peralta-Romero JJ; Unidad de Investigacion Medica en Bioquimica, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Cruz M; Unidad de Investigacion Medica en Bioquimica, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Valladares-Salgado A; Unidad de Investigacion Medica en Bioquimica, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. Electronic address: adanval@gmail.com.
Diabetes Metab Syndr ; 12(5): 631-633, 2018 Sep.
Article em En | MEDLINE | ID: mdl-29666032
AIM: To determine the association between the rs1256031 polymorphism and risk of developing type 2 diabetes. MATERIALS AND METHODS: Cases and controls study. 597 individuals with type 2 diabetes and 605 without it participated. Genotyping of the rs1256031 polymorphism of the ERß gene was performed by real-time PCR using TaqMan assay. For the multivariate analysis, a multiple logistic regression was performed that included the main confounding variables. RESULTS AND CONCLUSION: A multiple logistic regression analysis was performed, adjusting for age, WHR, BMI and gender. The dominant model showed a protective effect compared to the TT genotype (OR = 0.596, IC95% [0.458-0.776]). DISCUSSION: The proportions of native American, European and African ancestry were characterized and no difference was found in the study groups. The protective effect obtained in the dominant model could to be due a regulatory function in the transcription or the processing of the primary transcript. Our result are the first to report an association between the polymorphism rs1256031 and the reduction of the risk of T2D in the Mexican population. The rs1256031 polymorphism show reduced risk of developing T2D and is potential markers for predicting T2D.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Receptor beta de Estrogênio / Diabetes Mellitus Tipo 2 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Diabetes Metab Syndr Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Receptor beta de Estrogênio / Diabetes Mellitus Tipo 2 Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Mexico Idioma: En Revista: Diabetes Metab Syndr Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Holanda