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The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults.
Lopez-Lopez, Jose; Garay, Jennifer; Wandurraga, Edwin; Camacho, Paul A; Higuera-Escalante, Fernando; Cohen, Daniel; Lopez-Jaramillo, Patricio.
Afiliação
  • Lopez-Lopez J; Internal Medicine Residence Program, Universidad Autonoma de Bucaramanga (UNAB), Bucaramanga, Colombia.
  • Garay J; Internal Medicine Residence Program, Universidad Autonoma de Bucaramanga (UNAB), Bucaramanga, Colombia.
  • Wandurraga E; Endocrinology Service, Fundación Oftalmológica de Santander-Clínica Carlos Ardila Lulle (FOSCAL), Floridablanca, Colombia.
  • Camacho PA; Research Department, Fundacion Oftalmologica de Santander (FOSCAL), Floridablanca, Colombia.
  • Higuera-Escalante F; Facultad de ciencias de la Salud, Universidad Autonoma de Bucaramanga (UNAB), Bucaramanga, Colombia.
  • Cohen D; Higuera Escalante Laboratory, Floridablanca, Colombia.
  • Lopez-Jaramillo P; Research Department, Fundacion Oftalmologica de Santander (FOSCAL), Floridablanca, Colombia.
PLoS One ; 13(4): e0194446, 2018.
Article em En | MEDLINE | ID: mdl-29652881
INTRODUCTION: Guidelines recommend early detection of type 2 diabetes mellitus (DM2). The objective of the present study was to evaluate the capacity to identify DM2 in subjects that were screened for DM2 simultaneously with all three of the tests recommended-fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and a 2-hour post 75-g oral glucose tolerance test (OGTT). METHODS AND RESULTS: The present analysis of an anonymous database of 1113 adults from a reference clinical laboratory in Bucaramanga, Colombia, was an observational, descriptive, cross-sectional secondary source study. 259 individuals met at least one of the criteria for DM2: FPG ≥ 126mg/dL (7.0mmol/L), HbA1c ≥ 6.5% (48mmol/mol) and OGTT ≥ 200mg/dL (11.1mmol/L). 30 subjects (2.7%) were diabetic according to FPG, 56 subjects (5.0%) by HbA1c and 250 subjects (22.5%) by OGTT. In total 259 subjects (23.3% [IC 95%: 20.7%- 25.8%] were diabetic either by FPG, OGTT or HbA1c. DISCUSSION: The largest number of patients were identified as diabetic with the OGTT. The combination of two or three tests did not increase the detection of new cases of DM2. Our findings suggest that routinely requesting FPG, OGTT and HbA1c at the same time may be inappropriate in at risk individuals, as this approach does not significantly improve the diagnostic capacity compared to using FPG+OGTT and substantially increases the financial burden on the health system, insurers or individual.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Hemoglobinas Glicadas / Jejum / Diabetes Mellitus Tipo 2 Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Qualitative_research / Screening_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Hemoglobinas Glicadas / Jejum / Diabetes Mellitus Tipo 2 Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Qualitative_research / Screening_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Estados Unidos