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Risk factors and comorbidities in Brazilian patients with orofacial clefts.
Silva, Heglayne Pereira Vital da; Arruda, Thaynnan Thómaz Silva; Souza, Karla Simone Costa de; Bezerra, João Felipe; Leite, Gisele Correia Pacheco; Brito, Maria Edinilma Felinto de; Lima, Valéria Morgiana Gualberto Duarte Moreira; Luchessi, André Ducati; Bortolin, Raul Hernandes; Ururahy, Marcela Abbott Galvão; Rezende, Adriana Augusto de.
Afiliação
  • Silva HPVD; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Arruda TTS; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Souza KSC; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Bezerra JF; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Leite GCP; Department of Pediatrics, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Brito MEF; Department of Pediatrics, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Lima VMGDM; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Luchessi AD; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Bortolin RH; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Ururahy MAG; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
  • Rezende AA; Department of Clinical and Toxicological Analyses, Universidade Federal do Rio Grande do Norte - UFRN, Natal, RN, Brazil.
Braz Oral Res ; 32: e24, 2018.
Article em En | MEDLINE | ID: mdl-29641641
Considering that environmental risk factors substantially contribute to the etiology of orofacial clefts and that knowledge about the characteristics and comorbidities associated with oral clefts is fundamental to promoting better quality of life, this study aimed to describe the risk factors, main characteristics, and comorbidities of a group of patients with cleft lip and/or cleft palate (CL/P) from Rio Grande do Norte (RN), Brazil. Data were obtained from 173 patients with CL/P using a form from the Brazilian database on Orofacial Clefts. Most patients were male with cleft lip and palate and had a normal size and weight at birth; presented few neonatal intercurrent events; and had anemia and respiratory and cardiovascular diseases as main associated comorbidities. They also required timely surgical rehabilitation and multidisciplinary care to stimulate their neuropsychomotor development. In addition, a high frequency of familial recurrence and of parental consanguinity was evidenced in the studied population, especially for the cleft lip and cleft palate type. Other relevant findings were the considerable maternal exposure to alcohol, infections, smoking, and hypertension, as well as low supplementation with vitamins and minerals and deliberate consumption of analgesics, antibiotics, and antihypertensives during pregnancy. Characterization of the CL/P patient profile is essential for the planning of health services and integration among the health professionals involved in the diagnosis and treatment of these malformations. Our results reinforce the need for additional research to confirm the association between environmental factors and the development of orofacial clefts.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenda Labial / Fissura Palatina Tipo de estudo: Etiology_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz Oral Res Assunto da revista: ODONTOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenda Labial / Fissura Palatina Tipo de estudo: Etiology_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Pregnancy País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz Oral Res Assunto da revista: ODONTOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil