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Role of dietary α- and γ-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model.
Tapia, Gladys; Silva, David; Romero, Nalda; Pettinelli, Paulina; Dossi, Camila G; de Miguel, Manuel; González-Mañán, Daniel.
Afiliação
  • Tapia G; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Silva D; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
  • Romero N; Department of Food Science and Chemical Technology, University of Chile, Santiago, Chile.
  • Pettinelli P; Department of Health Sciences, Nutrition and Dietetics, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Dossi CG; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
  • de Miguel M; Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla, Sevilla, Spain.
  • González-Mañán D; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile. Electronic address: Danielgonzalez@med.uchile.cl.
Nutrition ; 53: 1-8, 2018 09.
Article em En | MEDLINE | ID: mdl-29625348
OBJECTIVE: The aim of this study was to evaluate the contribution of tocopherols present in Rosa mosqueta oil (RM) in the prevention of high-fat diet (HFD)-induced alterations. METHODS: Male C57 BL/6 J mice (n = 9/group) were fed for 12 wk and divided into four groups: control (CD; 10% kcal fat, 20% kcal protein, 70% kcal carbohydrates); HFD (60% as fat, 20% kcal protein, 20% kcal carbohydrates); HFD + RM (0.01 mL/g body weight/d); and HFD + RM- without tocopherols (0.01 mL/g body weight/d). Parameters of obesity, liver steatosis (histology, triacylglycerols content), inflammation (adipose NLRP3 inflammasome, tumor necrosis factor-α and interleukin-1 ß expression, hepatic nuclear factor-κB) and oxidative stress (hepatic Nrf2 activation, carbonylated proteins) were evaluated. RESULTS: Liver steatosis, inflammatory, and oxidative stress parameters were significantly (P < 0.05) increased in the HFD + RM- compared with the HFD + RM, with no differences between HFD and HFD + RM-. CONCLUSION: The present study suggests that α- and γ-tocopherols from RM may have an important role in the prevention of alterations induced by HFD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos de Plantas / Estresse Oxidativo / Rosa / Alfa-Tocoferol / Gama-Tocoferol / Dieta Hiperlipídica / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nutrition Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos de Plantas / Estresse Oxidativo / Rosa / Alfa-Tocoferol / Gama-Tocoferol / Dieta Hiperlipídica / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nutrition Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos