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Maternal dietary intake of polyunsaturated fatty acids modifies association between prenatal DDT exposure and child neurodevelopment: A cohort study.
Ogaz-González, Rafael; Mérida-Ortega, Ángel; Torres-Sánchez, Luisa; Schnaas, Lourdes; Hernández-Alcaraz, César; Cebrián, Mariano E; Rothenberg, Stephen J; García-Hernández, Rosa María; López-Carrillo, Lizbeth.
Afiliação
  • Ogaz-González R; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico. Electronic address: rafaogaz@hotmail.com.
  • Mérida-Ortega Á; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico. Electronic address: angel.merida@espm.insp.mx.
  • Torres-Sánchez L; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico. Electronic address: ltorress@insp.mx.
  • Schnaas L; Subdirección de Investigación en Intervenciones Comunitarias, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Calle Montes Urales 800, Miguel Hidalgo, Lomas Virreyes, Ciudad de México, Mexico. Electronic address: lschnaas@hotmail.com.
  • Hernández-Alcaraz C; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico. Electronic address: cesar.hernandez@insp.mx.
  • Cebrián ME; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Av. Instituto Politécnico Nacional, 2508, Delegación Gustavo A. Madero, San Pedro Zacatenco, Ciudad de México, Mexico. Electronic address: mcebrian@cinvestav.mx.
  • Rothenberg SJ; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico. Electronic address: rothenberg@insp.mx.
  • García-Hernández RM; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Av. Instituto Politécnico Nacional, 2508, Delegación Gustavo A. Madero, San Pedro Zacatenco, Ciudad de México, Mexico. Electronic address: rmgarcia@cinvestav.mx.
  • López-Carrillo L; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Av. Universidad 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico. Electronic address: lizbeth@insp.mx.
Environ Pollut ; 238: 698-705, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29621729
BACKGROUND: Maternal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) serum levels during pregnancy have been negatively linked to child neurodevelopment in contrast to intake of omega-3 and -6 (ω-3 and ω-6) fatty acids. OBJECTIVES: To assess whether maternal dietary intake of ω-3 and ω-6 during pregnancy modifies the association between exposure to DDE and child neurodevelopment from age 42-60 months. METHODS: Prospective cohort study with 142 mother-child pairs performed in Mexico. DDE serum levels were determined by electron capture gas chromatography. Dietary ω-3 and ω-6 intake was estimated by questionnaire. Child neurodevelopment was assessed by McCarthy Scales. RESULTS: Docosahexaenoic (DHA) fatty acid intake significantly modified the association between DDE and motor component: increased maternal DDE was associated with lower motor development in children whose mothers had lower DHA intake (ßlog2DDE = -1.25; 95% CI: -2.62, 0.12), in contrast to the non-significant increase among children whose mothers had higher DHA intake (ßlog2DDE-motor = 0.50; 95% CI: 0.55, 1.56). Likewise, arachidonic fatty acid (ARA) intake modified the association between DDE and memory component: increased maternal DDE was associated with a significantly larger reduction in the memory component in children whose mothers had lower ARA intake (ßlog2DDE = -1.31; 95% CI: -2.29, -0.32) than children whose mothers had higher ARA intake (ßlog2DDE-memory = 0.17; 95% CI: -0.78, 1.11). CONCLUSIONS: Dietary intake of DHA and ARA during pregnancy may protect against child neurodevelopment damage associated with prenatal maternal DDE levels.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Praguicidas / Desenvolvimento Infantil / Exposição Materna / DDT / Poluentes Ambientais / Ácidos Graxos Insaturados / Exposição Dietética Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Child / Child, preschool / Female / Humans / Infant / Male / Pregnancy País/Região como assunto: Mexico Idioma: En Revista: Environ Pollut Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Praguicidas / Desenvolvimento Infantil / Exposição Materna / DDT / Poluentes Ambientais / Ácidos Graxos Insaturados / Exposição Dietética Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Child / Child, preschool / Female / Humans / Infant / Male / Pregnancy País/Região como assunto: Mexico Idioma: En Revista: Environ Pollut Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido