A case-control study of breast cancer and hormonal contraception in Costa Rica.
J Natl Cancer Inst
; 79(6): 1247-54, 1987 Dec.
Article
em En
| MEDLINE
| ID: mdl-2961909
ABSTRACT
PIP: Depot-medroxyprogesterone acetate (DMPA) is used by approximately 2 million women world-wide. In Costa Rica, by 1981 11% of the married women had used DMPA. Although no definitive link between the use of DMPA and the development of cancer has been found, the possibility has been recognized as one of the reasons for the U.S food and Drug Administration denying approval of the drug. Since 1977, the Ministry of Health in Costa Rica has sustained a national cancer registry. The accuracy of the reporting of the registry was studied by comparing a sampling of gynecologic cancer cases in the year 1983 to the national registry. In examination of the records, an elevated relative risk of breast cancer for DMPA users was found (2.6), and an elevated relative risk for women who had even used DMPA for a short period of time (2.3). The failure to interview 1/3 of the cases, differences in detection and the misclassification of DMPA use contributed cumulatively to the belief that a positive connection between breast cancer and DMPA use could otherwise be drawn. In contrast to the association found between DMPA ever use and breast cancer, no connection was found between OC use and the incidence of breast cancer. However, due to the small number of DMPA users recorded and the void of complete and accurate recorded information, the study results remain inconclusive.
Palavras-chave
Americas; Breast Cancer; Cancer; Central America; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Methods; Costa Rica; Developing Countries; Diseases; Family Planning; Latin America; Medroxyprogesterone Acetate; Neoplasms; North America; Oral Contraceptives
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Anticoncepcionais Orais
/
Medroxiprogesterona
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
America central
/
Costa rica
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
1987
Tipo de documento:
Article
País de publicação:
Estados Unidos