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The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.
Marchese, Letícia; Nascimento, Janaina de Freitas; Damasceno, Flávia Silva; Bringaud, Frédéric; Michels, Paul A M; Silber, Ariel Mariano.
Afiliação
  • Marchese L; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, Brazil. lets.marchese@gmail.com.
  • Nascimento JF; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, Brazil. janaina_biomed@hotmail.com.
  • Damasceno FS; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, Brazil. flaviadamasceno@usp.br.
  • Bringaud F; Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux, CNRS UMR-5234, 146, rue Léo Saignat, Zone Nord, Bâtiment 3A, 33076 Bordeaux, France. frederic.bringaud@u-bordeaux.fr.
  • Michels PAM; Centre for Immunity, Infection and Evolution and Centre for Translational and Chemical Biology, School of Biological Sciences, Ashworth Laboratories, Charlotte Auerbach Road, The University of Edinburgh, Edinburgh EH9 3FL, UK. paul.michels@ed.ac.uk.
  • Silber AM; Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, Brazil. asilber@usp.br.
Pathogens ; 7(2)2018 Apr 01.
Article em En | MEDLINE | ID: mdl-29614775
Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pathogens Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pathogens Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça