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Estrogen receptor ß activation within dorsal raphe nucleus reverses anxiety-like behavior induced by food restriction in female rats.
Campos, Glenda Viggiano; de Noronha, Sylvana Rendeiro; de Souza, Aline Arlindo; Lima, Paulo Marcelo; Abreu, Aline Rezende; Chianca-Jr, Deoclecio; de Menezes, Rodrigo Cunha.
Afiliação
  • Campos GV; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Biological Sciences CBIOL/NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil.
  • de Noronha SR; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Biological Sciences CBIOL/NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil.
  • de Souza AA; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Biological Sciences CBIOL/NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil.
  • Lima PM; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Biological Sciences CBIOL/NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil.
  • Abreu AR; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Biological Sciences CBIOL/NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil.
  • Chianca-Jr D; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Biological Sciences CBIOL/NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil.
  • de Menezes RC; Department of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, MG, Brazil; Graduate Program in Biological Sciences CBIOL/NUPEB, Federal University of Ouro Preto, Ouro Preto, Brazil. Electronic address: rodrigo.menezes@iceb.ufop.br.
Behav Brain Res ; 357-358: 57-64, 2019 01 14.
Article em En | MEDLINE | ID: mdl-29567265
Severe food restriction (FR), as observed in disorders like anorexia nervosa, has been associated to the reduction of estrogen levels, which in turn could lead to anxiety development. Estrogen receptors, mainly ERß type, are commonly found in the dorsal raphe nucleus (DRN) neurons, an important nucleus related to anxiety modulation and the primary source of serotonin (5-HT) in the brain. Taking together, these findings suggest an involvement of estrogen in anxiety modulation during food restriction, possibly mediated by ERß activation in serotonergic DRN neurons. Thus, the present study investigated the relationship between food restriction and anxiety-like behavior, and the involvement of DRN and ERß on the modulation of anxiety-like behaviors in animals subjected to FR. For that, female Fischer rats were grouped in control group, with free access to food, or a FR group, which received 40% of control intake during 14 days. Animals were randomly treated with 17ß-estradiol (E2), DPN (ERß selective agonist), or their respective vehicles, PBS and DMSO. Behavioral tests were performed on Elevated T-Maze (ETM) and Open Field (OF). Our results suggest that FR probably reduced the estrogen levels, since the remained in the non-ovulatory cycle phases, and their uterine weight was lower when compared to control group. The FR rats showed increased inhibitory avoidance latency in theETM indicating that FR is associated with the development of an anxiety-like state. The injections of both E2 and DPN into DRN of FR animals had an anxiolytic effect. Those data suggest thatanxiety-like behavior induced by FR could be mediated by a reduction of ERß activation in the DRN neurons, probably due to decreased estrogen levels.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Núcleos da Rafe / Receptor beta de Estrogênio / Privação de Alimentos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiedade / Núcleos da Rafe / Receptor beta de Estrogênio / Privação de Alimentos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda