Gold-Catalyzed Addition of ß-Ketoesters to Alkenes: Influence of Electronic and Steric Effects in the Reaction Outcome.
Molecules
; 23(3)2018 Mar 10.
Article
em En
| MEDLINE
| ID: mdl-29534449
The gold-catalyzed intermolecular hydroalkylation of olefins with ß-ketoesters represents a conceptually attractive and useful synthetic tool; however, it has been scarcely applied, remaining a challenge for chemists. The aim of the current study was to investigate the addition of these 1,3-diketo-compounds to alkenes under gold catalysis conditions, in order to establish the electronic and steric effects of the alkenyl substrates in the reaction outcome. The screening of different catalyst systems and diverse olefins enabled defining the alkenyl requirements and the best reaction conditions to efficiently achieve the coupled products.
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MEDLINE
Assunto principal:
Alcenos
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Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Suíça