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Intradialytic neuromuscular electrical stimulation reduces DNA damage in chronic kidney failure patients: a randomized controlled trial.
Schardong, Jociane; Brito, Verônica Bidinotto; Dipp, Thiago; Macagnan, Fabrício Edler; Saffi, Jenifer; Méa Plentz, Rodrigo Della.
Afiliação
  • Schardong J; a Department of Physical Therapy , Universidade Federal de Ciencias da Saude de Porto Alegre , Porto Alegre , Brazil.
  • Brito VB; a Department of Physical Therapy , Universidade Federal de Ciencias da Saude de Porto Alegre , Porto Alegre , Brazil.
  • Dipp T; a Department of Physical Therapy , Universidade Federal de Ciencias da Saude de Porto Alegre , Porto Alegre , Brazil.
  • Macagnan FE; a Department of Physical Therapy , Universidade Federal de Ciencias da Saude de Porto Alegre , Porto Alegre , Brazil.
  • Saffi J; a Department of Physical Therapy , Universidade Federal de Ciencias da Saude de Porto Alegre , Porto Alegre , Brazil.
  • Méa Plentz RD; a Department of Physical Therapy , Universidade Federal de Ciencias da Saude de Porto Alegre , Porto Alegre , Brazil.
Biomarkers ; 23(5): 495-501, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29529880
BACKGROUND: Chronic kidney failure (CKF) patients on renal replacement therapies exhibit elevated levels of DNA lesions and this is directly related to high mortality. OBJECTIVE: This study aimed to evaluate the effect of neuromuscular electrical stimulation (NMES) on genomic damage in CKF patients on conventional haemodialysis (HD). METHODS: Twenty-one patients with CKF on HD were randomized into control (CG =10) or neuromuscular electrical stimulation (NMESG = 11) groups. NMES was applied on the quadriceps muscle during the HD session, three times a week, for 8 weeks in NMESG. DNA damage in blood was evaluated by the alkaline comet assay prior to follow-up, after 4 and 8 weeks of intervention. RESULTS: Intradialytic NMES in CKF patients induced a significant decrease in DNA damage after four [49.9 (3.68) vs 101.5 (6.53); p = 0.000] than eight [19.9 (2.07) vs 101.5 (6.53); p = 0.000] weeks compared to baseline. Genomic damage was also significantly less after four [NMESG: 49.9 (3.68) vs CG: 92.9 (12.61); p = 0.001] than after eight [NMESG: 19.9 (2.07) vs CG: 76.4 (11.15); p = 0.000] weeks compared to CG. CONCLUSIONS: This study demonstrates for the first time that intradialytic NMES is able to reduce DNA damage in blood of CKF patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Estimulação Elétrica / Falência Renal Crônica Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biomarkers Assunto da revista: BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Estimulação Elétrica / Falência Renal Crônica Tipo de estudo: Clinical_trials Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biomarkers Assunto da revista: BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido