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The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung.
Galvão, Izabela; Tavares, Luciana P; Corrêa, Renan O; Fachi, José Luís; Rocha, Vitor Melo; Rungue, Marcela; Garcia, Cristiana C; Cassali, Geovanni; Ferreira, Caroline M; Martins, Flaviano S; Oliveira, Sergio C; Mackay, Charles R; Teixeira, Mauro M; Vinolo, Marco Aurélio R; Vieira, Angélica T.
Afiliação
  • Galvão I; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Tavares LP; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Corrêa RO; Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Fachi JL; Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Rocha VM; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Rungue M; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Garcia CC; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
  • Cassali G; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Ferreira CM; Department of Pharmaceutics Sciences, Institute of Environmental, Chemistry and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, Brazil.
  • Martins FS; Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Oliveira SC; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Mackay CR; Department of Immunology, Monash University, Melborne, VIC, Australia.
  • Teixeira MM; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
  • Vinolo MAR; Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Vieira AT; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Front Immunol ; 9: 142, 2018.
Article em En | MEDLINE | ID: mdl-29515566
Pneumonia is one of the leading causes of death and mortality worldwide. The inflammatory responses that follow respiratory infections are protective leading to pathogen clearance but can also be deleterious if unregulated. The microbiota is known to be an important protective barrier against infections, mediating both direct inhibitory effects against the potential pathogen and also regulating the immune responses contributing to a proper clearance of the pathogen and return to homeostasis. GPR43 is one receptor for acetate, a microbiota metabolite shown to induce and to regulate important immune functions. Here, we addressed the role of GPR43 signaling during pulmonary bacterial infections. We have shown for the first time that the absence of GPR43 leads to increased susceptibility to Klebsiella pneumoniae infection, which was associated to both uncontrolled proliferation of bacteria and to increased inflammatory response. Mechanistically, we showed that GPR43 expression especially in neutrophils and alveolar macrophages is important for bacterial phagocytosis and killing. In addition, treatment with the GPR43 ligand, acetate, is protective during bacterial lung infection. This was associated to reduction in the number of bacteria in the airways and to the control of the inflammatory responses. Altogether, GPR43 plays an important role in the "gut-lung axis" as a sensor of the host gut microbiota activity through acetate binding promoting a proper immune response in the lungs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Klebsiella / Receptores Acoplados a Proteínas G / Klebsiella pneumoniae Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Klebsiella / Receptores Acoplados a Proteínas G / Klebsiella pneumoniae Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça