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Transcranial Doppler velocity among Jamaican children with sickle cell anaemia: determining the significance of haematological values and nutrition.
Rankine-Mullings, Angela E; Morrison-Levy, Nadine; Soares, Deanne; Aldred, Karen; King, Lesley; Ali, Susanna; Knight-Madden, Jennifer M; Wisdom-Phipps, Margaret; Adams, Robert J; Ware, Russell E; Reid, Marvin.
Afiliação
  • Rankine-Mullings AE; Sickle Cell Unit, Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica.
  • Morrison-Levy N; Sickle Cell Unit, Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica.
  • Soares D; Tropical Metabolism Research Unit, Caribbean Institute for Health Research Institute, University of the West Indies, Kingston, Jamaica.
  • Aldred K; Sickle Cell Unit, Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica.
  • King L; Sickle Cell Unit, Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica.
  • Ali S; Sickle Cell Unit, Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica.
  • Knight-Madden JM; Sickle Cell Unit, Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica.
  • Wisdom-Phipps M; Sickle Cell Unit, Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica.
  • Adams RJ; Neurology, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
  • Ware RE; Cincinnati Children's Hospital Medical Centre, Cincinnati, OH, USA.
  • Reid M; Tropical Metabolism Research Unit, Caribbean Institute for Health Research Institute, University of the West Indies, Kingston, Jamaica.
Br J Haematol ; 181(2): 242-251, 2018 04.
Article em En | MEDLINE | ID: mdl-29504121
This study investigated the association of nutritional and haematological variables with maximum time-averaged mean velocity (TAMV) measured by transcranial Doppler (TCD) velocity and the agreement of classification between two protocols. TCD categories included: normal (<170 cm/s), conditional (170-199 cm/s) and abnormal (≥200 cm/s) based on TAMV in distal internal carotid artery (dICA), middle cerebral artery (MCA), internal carotid bifurcation, anterior and posterior cerebral arteries. Of 358 children with sickle cell anaemia (SCA) examined, the mean age (±standard deviation) was 7·4 ± 2·7 years; 13·1% and 6·7% had conditional and abnormal velocities, respectively. Children with abnormal TCD velocities had higher prevalence of prior stroke (P = 0·006). Increased TAMV was associated with younger age (P = 0·001), lower weight (P = 0·001), height (P = 0·007) and oxygen saturation (P = 0·005). There was no association of TAMV with height-age or body mass index (BMI) z-scores. Adjusting for gender, BMI z-score, age, previous stroke and oxygen saturation, mean corpuscular volume (P = 0·005) and reticulocyte count (P = 0·013) were positively associated with TAMV, while haemoglobin concentration (P = 0·009) was negatively associated. There was good agreement [99%; weighted Kappa 0·98 (95% confidence interval 0·89-1), P = 0·0001] in TCD classification using data from five vessels versus two vessels (dICA and MCA). Haematological variables, rather than nutritional status, may be useful markers that identify high-risk children with SCA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobinas / Artérias Cerebrais / Circulação Cerebrovascular / Estado Nutricional / Ultrassonografia Doppler Transcraniana / Anemia Falciforme Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male País/Região como assunto: Caribe ingles / Jamaica Idioma: En Revista: Br J Haematol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Jamaica País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobinas / Artérias Cerebrais / Circulação Cerebrovascular / Estado Nutricional / Ultrassonografia Doppler Transcraniana / Anemia Falciforme Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Child, preschool / Female / Humans / Male País/Região como assunto: Caribe ingles / Jamaica Idioma: En Revista: Br J Haematol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Jamaica País de publicação: Reino Unido