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Pulmonary Hypertension Associated with Hypoxic-Ischemic Encephalopathy-Antecedent Characteristics and Comorbidities.
Lakshminrusimha, Satyan; Shankaran, Seetha; Laptook, Abbot; McDonald, Scott; Keszler, Martin; Van Meurs, Krisa; Guillet, Ronnie; Chawla, Sanjay; Sood, Beena G; Bonifacio, Sonia; Das, Abhik; Higgins, Rosemary D.
Afiliação
  • Lakshminrusimha S; Department of Pediatrics, University of California at Davis, Sacramento, CA. Electronic address: slakshmi@ucdavis.edu.
  • Shankaran S; Department of Pediatrics, Wayne State University, Detroit, MI.
  • Laptook A; Department of Pediatrics, Brown University, Providence, RI.
  • McDonald S; RTI International, Research Triangle Park, NC.
  • Keszler M; Department of Pediatrics, Brown University, Providence, RI.
  • Van Meurs K; Department of Pediatrics, Stanford University, Palo Alto, CA.
  • Guillet R; Department of Pediatrics, University of Rochester, Rochester, NY.
  • Chawla S; Department of Pediatrics, Wayne State University, Detroit, MI.
  • Sood BG; Department of Pediatrics, Wayne State University, Detroit, MI.
  • Bonifacio S; Department of Pediatrics, Stanford University, Palo Alto, CA.
  • Das A; RTI International, Rockville, MD.
  • Higgins RD; NICHD, Bethesda, MD.
J Pediatr ; 196: 45-51.e3, 2018 05.
Article em En | MEDLINE | ID: mdl-29502880
OBJECTIVE: To determine the characteristics of term infants with persistent pulmonary hypertension of the newborn (PPHN) associated with moderate or severe hypoxic ischemic encephalopathy (HIE). METHODS: We compared infants with and without PPHN enrolled in 2 randomized trials of therapeutic hypothermia: the induced hypothermia trial of cooling to 33.5°C for 72 hours vs normothermia, and the "usual-care" arm (33.5°C for 72 hours) of the optimizing cooling trial. RESULTS: Among 303 infants with HIE from these 2 studies, 67 (22%) had PPHN and 236 (78%) did not. We compared infants with PPHN with those without PPHN. The proportion of patients treated with therapeutic hypothermia was similar in PPHN and no-PPHN groups (66% vs 65%). Medication use during resuscitation (58% vs 44%), acidosis after birth (pH: 7.0 ± 0.2 vs 7.1 ± 0.2), severe HIE (43% vs 28%), meconium aspiration syndrome (39% vs 7%), pulmonary hemorrhage (12% vs 3%), culture-positive sepsis (12% vs 3%), systemic hypotension (65% vs 28%), inhaled nitric oxide therapy (64% vs 3%), and extracorporeal membrane oxygenation (12% vs 0%) were more common in the PPHN group. Length of stay (26 ± 21 vs 16 ± 14 days) and mortality (27% vs 16%) were higher in the PPHN group. CONCLUSIONS: PPHN is common among infants with moderate/severe HIE and is associated with severe encephalopathy, lung disease, sepsis, systemic hypotension, and increased mortality. The prevalence of PPHN was not different between those infants receiving therapeutic hypothermia at 33.5°C in these 2 trials (44/197 = 22%) compared with infants receiving normothermia in the induced hypothermia trial (23/106 = 22%).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asfixia Neonatal / Hipóxia-Isquemia Encefálica / Hipertensão Pulmonar / Hipotermia Induzida Tipo de estudo: Clinical_trials / Diagnostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asfixia Neonatal / Hipóxia-Isquemia Encefálica / Hipertensão Pulmonar / Hipotermia Induzida Tipo de estudo: Clinical_trials / Diagnostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos