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In transit sentinel node drainage as a prognostic factor for patients with cutaneous melanoma.
Brandão, Paulo H D M; Bertolli, Eduardo; Doria-Filho, Eduardo; Santos Filho, Ivan D A O; de Macedo, Mariana P; Pinto, Clovis A L; Duprat Neto, João P.
Afiliação
  • Brandão PHDM; Surgical Oncology Medical Residence Program, AC Camargo Cancer Center, São Paulo, Brazil.
  • Bertolli E; Skin Cancer Department, AC Camargo Cancer Center, São Paulo, Brazil.
  • Doria-Filho E; Surgical Oncology Medical Residence Program, AC Camargo Cancer Center, São Paulo, Brazil.
  • Santos Filho IDAO; Skin Cancer Department, AC Camargo Cancer Center, São Paulo, Brazil.
  • de Macedo MP; Pathology, AC Camargo Cancer Center, São Paulo, Brazil.
  • Pinto CAL; Pathology, AC Camargo Cancer Center, São Paulo, Brazil.
  • Duprat Neto JP; Skin Cancer Department, AC Camargo Cancer Center, São Paulo, Brazil.
J Surg Oncol ; 117(5): 864-867, 2018 Apr.
Article em En | MEDLINE | ID: mdl-29484669
BACKGROUND: Minor basin or in transit node drainage can be found in patients with cutaneous melanoma who undergo sentinel node biopsy. Its clinical impact is still unclear. Our objective is to evaluate clinical outcomes in patients who presented with in transit sentinel node (ITN) drainage. MATERIAL AND METHODS: Retrospective analysis of patients who underwent sentinel node biopsy (SNB) in a single Brazilian institution between 2000 and 2015. RESULTS: Our cohort comprised 1223 SNB. There were 64 patients (5.2%) with ITN. Melanoma of the limbs (OR 10.61, P < 0.0001) and acral subtype (OR 3.49, P < 0.0001) were associated with ITN drainage. Among these 64 patients, 14 (21.9%) had a positive SNB. The ITN was positive for metastases in five patients, four in a popliteal basin and one on the trunk. Regarding completion node dissection (CND), two patients had positive non-sentinel nodes (NSN), both in major basins. In patients who developed recurrence, time to recurrence was shorter (mean time 18 vs 31.4 months, P = 0.001) and time to death was shorter (mean time 31.6 vs 40 months, P = 0.039) in those who had ITN drainage. CONCLUSION: ITN drainage was associated with earlier recurrences and deaths from melanoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Drenagem / Biópsia de Linfonodo Sentinela / Linfonodo Sentinela / Melanoma / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: J Surg Oncol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Drenagem / Biópsia de Linfonodo Sentinela / Linfonodo Sentinela / Melanoma / Recidiva Local de Neoplasia Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: J Surg Oncol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos