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Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model.
Cortes-Altamirano, José Luis; Reyes-Long, Samuel; Olmos-Hernández, Adriana; Bonilla-Jaime, Herlinda; Carrillo-Mora, Paul; Bandala, Cindy; Alfaro-Rodriguez, Alfonso.
Afiliação
  • Cortes-Altamirano JL; PhD Program in Biological and Health Sciences, Universidad Autónoma Metropolitana (UAM) Iztapalapa-Xochimilco-Cuajimalpa, Mexico City, Mexico.
  • Reyes-Long S; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, Estado de México, Mexico.
  • Olmos-Hernández A; Department of Neurosciences, National Rehabilitation Institute "Luis Guillermo Ibarra Ibarra" (INR) Secretaría de Salud (SSA), Mexico City, Mexico.
  • Bonilla-Jaime H; Departament of Reproductive Biology, Universidad Autónoma Metropolitana (UAM) Campus Iztapalapa, Mexico City, Mexico.
  • Carrillo-Mora P; Department of Neurosciences, National Rehabilitation Institute "Luis Guillermo Ibarra Ibarra" (INR) Secretaría de Salud (SSA), Mexico City, Mexico.
  • Bandala C; Department of Neurosciences, National Rehabilitation Institute "Luis Guillermo Ibarra Ibarra" (INR) Secretaría de Salud (SSA), Mexico City, Mexico.
  • Alfaro-Rodriguez A; Department of Neurosciences, National Rehabilitation Institute "Luis Guillermo Ibarra Ibarra" (INR) Secretaría de Salud (SSA), Mexico City, Mexico. Electronic address: alfa1360@yahoo.com.mx.
Pharmacol Rep ; 70(2): 385-389, 2018 Apr.
Article em En | MEDLINE | ID: mdl-29477948
BACKGROUND: Levetiracetam (LEV) is a novel anticonvulsant with proven antinociceptive properties. However, the antinociceptive and pronociceptive effect of this drug has not yet been fully elucidated in a tonic pain model. METHODS: Thirty-six male rats (Wistar) were randomized into six groups and underwent the formalin test as follows: rats in the control group were administered 50µL of 1% formalin in the paw; sham-group rats were administered 50µL of saline in the paw to mimick the application of formalin; the four experimental groups were administered LEV intragastrically (ig) (50, 100, 200 and 300mg/kg), and 40min later 50µL of 1% formalin was injected in the paw. RESULTS: LEV exhibited antinociceptive effect in the 300mg/kg LEV group (p<0.05) and a pronociceptive effect in the 100mg/kg LEV group (p<0.05) and in the 50mg/kg LEV group (p<0.001). CONCLUSIONS: The antinociceptive and pronociceptive effect of LEV in a tonic pain model is dose-dependent.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Piracetam / Nociceptividade / Anticonvulsivantes Limite: Animals Idioma: En Revista: Pharmacol Rep Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Piracetam / Nociceptividade / Anticonvulsivantes Limite: Animals Idioma: En Revista: Pharmacol Rep Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Suíça