Intranasal nafarelin: an LH-RH analogue treatment of gonadotropin-dependent precocious puberty.
J Pediatr
; 109(6): 954-8, 1986 Dec.
Article
em En
| MEDLINE
| ID: mdl-2946840
The agonistic analogues of luteinizing hormone releasing hormone decrease biochemical findings and clinical signs of gonadotropin-dependent precocious puberty. We tested a new analogue, nafarelin acetate, in 15 girls with gonadotropin-dependent precocious puberty. The hydrophobic nature and potency of this compound allow it to be administered by intranasal inhalation. Laboratory assessment of vaginal cytology, estradiol and urinary gonadotropin levels, and growth velocity revealed that nafarelin acetate 800 to 1200 micrograms/day diminished these values during a 6-month treatment period. These results suggest gonadotropin-dependent precocious puberty in girls can be treated with intranasal administration of nafarelin acetate.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
/
Hormônio Liberador de Gonadotropina
/
Gonadotropinas Hipofisárias
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
1986
Tipo de documento:
Article
País de publicação:
Estados Unidos