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Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma.
Moron, Roberson A; Jacob, Carlos Eduardo; Bresciani, Claudio José Caldas; Simões, Kleber; Alves, Venâncio Avancini Ferreira; Irya, Kyoshi; Gama-Rodrigues, Joaquim; Cecconello, Ivan; Longatto-Filho, Adhemar; Zilberstein, Bruno.
Afiliação
  • Moron RA; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Jacob CE; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Bresciani CJC; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Simões K; Department of Pathology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Alves VAF; Department of Pathology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Irya K; Department of Pathology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Gama-Rodrigues J; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Cecconello I; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Longatto-Filho A; Department of Pathology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
  • Zilberstein B; Department of Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University of São Paulo School of Medicine, São Paulo, SP 14784-400, Brazil.
Mol Clin Oncol ; 8(3): 477-482, 2018 Mar.
Article em En | MEDLINE | ID: mdl-29468062
The aim of the present study was to determine the clinical significance of p53 and p21ras p21wafl, p27kip1 and p16ink4a expression in cases of early gastric cancer. A total of 81 patients who had undergone gastrectomy with D2 lymphadenectomy between 1971 and 2004 were retrospectively investigated. The immunohistochemical expression of p21ras, p53, p21waf1/cip1, p27kip1 and p16ink4a in the tissues was evaluated. In normal, metaplastic and tumoral mucosa, p53 was positive in 53, 87.3, and 87.1% of the cases, respectively. In the same tissues, p21ras was positivE in 85.3, 86 and 96.8%, respectively. Positivity FOR p16ink4a was DETECTED IN 46.3, 91.1 and 86% OF THE CASES, respectively, WHEREAS p27kip1 WAS positiVE IN 60, 94.7 and 95.3%, and p21wafl/cip1 WAS positivE IN 32.4, 72.7 and 71.4% OF THE CASES, respectively. All THE tumors WERE positive for p53. Tumors with lymph node invasion presented WITH OVERexpression (+4) of p53 in 47% of the cases VS. 17% OF patients who DID not HAVE lymph node involvement. THEREFORE, higher expression of p53, p21ras and p21wafl/cip1 IN the tumor exhibited a statistically significant association with lymph node involvement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Clin Oncol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mol Clin Oncol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido