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Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis.
Yazbek, Daniel Constantino; Carvalho, Aluizio Barbosa; Barros, Cinara Sa; Medina Pestana, Jose Osmar; Rochitte, Carlos Eduardo; Dos Santos Filho, Raul Dias; Canziani, Maria Eugênia F.
Afiliação
  • Yazbek DC; Nephrology Division, Federal University of Sao Paulo, São Paulo, Brazil.
  • Carvalho AB; Nephrology Division, Federal University of Sao Paulo, São Paulo, Brazil.
  • Barros CS; Nephrology Division, Federal University of Sao Paulo, São Paulo, Brazil.
  • Medina Pestana JO; Nephrology Division, Federal University of Sao Paulo, São Paulo, Brazil.
  • Rochitte CE; Cardiovascular Magnetic Resonance and Computed Tomography Sector, Heart Institute (InCor), University of São Paulo, Medical School, São Paulo, Brazil.
  • Dos Santos Filho RD; Lipid Clinic Heart Institute (InCor) University of Sao Paulo Medical School, São Paulo, Brazil.
  • Canziani MEF; Nephrology Division, Federal University of Sao Paulo, São Paulo, Brazil.
PLoS One ; 13(2): e0191009, 2018.
Article em En | MEDLINE | ID: mdl-29466361
BACKGROUND: Epicardial fat (EF) has been related to increased cardiovascular risk in chronic kidney disease patients. Kidney transplantation is associated with weight gain, especially within the first 12 months. Recently an association between EF and left ventricular mass (LVM) has been suggested in kidney transplant (KTX) recipients. OBJECTIVE: Evaluate the EF in KTX recipients and its association with cardiovascular parameters in a 12-month follow-up study. METHODS: EF volume was determined using thoracic computed tomography. The EF progressor group (EF gain) was defined by any increment in EF after 12 months. LVM and LVM index were calculated by echocardiography. RESULTS: Ninety-eight incident KTX patients [57% men, 41.2 ± 10.1 years, mean dialysis time prior to transplant of 24 (11-60) months] were analyzed. At baseline and after 12 months, EF was 318.6 (275.2-392.6) ml and 329.5 (271.7-384.8) ml, respectively (p = 0.03). When compared to patients who EF decreased (n = 33), those with EF gain (n = 65) had a greater increase of body mass index, abdominal circumference and blood glucose. These patients also had a lower reduction of LVM index. However in the multivariate analysis, there was no difference in LVM index change between groups (interaction p = 0.565), even after adjustment for hypertension, glucose and coronary calcium score (interaction p = 0.538). CONCLUSION: The impact of EF gain on ventricular mass after KTX could not be definitely confirmed. Further prospective studies in a large sample of KTX patients should be considered to address a possible causal relationship between EF gain and cardiac hypertrophy in this population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pericárdio / Doenças Cardiovasculares / Transplante de Rim Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pericárdio / Doenças Cardiovasculares / Transplante de Rim Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos