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Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity.
Dos Santos Souza, Cleide; Grangeiro, Maria Socorro; Lima Pereira, Erica Patricia; Dos Santos, Cleonice Creusa; da Silva, Alessandra Bispo; Sampaio, Geraldo Pedral; Ribeiro Figueiredo, Daiana Dias; David, Jorge Mauricio; David, Juceni Pereira; da Silva, Victor Diogenes Amaral; Butt, Arthur Morgan; Lima Costa, Silvia.
Afiliação
  • Dos Santos Souza C; Department of Biochemistry and Biophysics, Institute of Health Sciences, Universidade Federal da Bahia, Brazil.
  • Grangeiro MS; Department of Biochemistry and Biophysics, Institute of Health Sciences, Universidade Federal da Bahia, Brazil.
  • Lima Pereira EP; Department of Biochemistry and Biophysics, Institute of Health Sciences, Universidade Federal da Bahia, Brazil.
  • Dos Santos CC; Department of Biochemistry and Biophysics, Institute of Health Sciences, Universidade Federal da Bahia, Brazil.
  • da Silva AB; Department of Biochemistry and Biophysics, Institute of Health Sciences, Universidade Federal da Bahia, Brazil.
  • Sampaio GP; Department of Biochemistry and Biophysics, Institute of Health Sciences, Universidade Federal da Bahia, Brazil.
  • Ribeiro Figueiredo DD; Departament of Medication, Faculty of Pharmacy, Universidade Federal da Bahia, Brazil.
  • David JM; Department of General and Inorganic Chemistry, Institute of Chemistry, Universidade Federal da Bahia, Brazil.
  • David JP; Departament of Medication, Faculty of Pharmacy, Universidade Federal da Bahia, Brazil.
  • da Silva VDA; Department of Biochemistry and Biophysics, Institute of Health Sciences, Universidade Federal da Bahia, Brazil.
  • Butt AM; School of Pharmacy and Biomedical Science, University of Portsmouth, United Kingdom.
  • Lima Costa S; Department of Biochemistry and Biophysics, Institute of Health Sciences, Universidade Federal da Bahia, Brazil. Electronic address: costasl@ufba.br.
Neurotoxicology ; 65: 85-97, 2018 03.
Article em En | MEDLINE | ID: mdl-29425760
Flavonoids are bioactive compounds that are known to be neuroprotective against glutamate-mediated excitotoxicity, one of the major causes of neurodegeneration. The mechanisms underlying these effects are unresolved, but recent evidence indicates flavonoids may modulate estrogen signaling, which can delay the onset and ameliorate the severity of neurodegenerative disorders. Furthermore, the roles played by glial cells in the neuroprotective effects of flavonoids are poorly understood. The aim of this study was to investigate the effects of the flavonoid agathisflavone (FAB) in primary neuron-glial co-cultures from postnatal rat cerebral cortex. Compared to controls, treatment with FAB significantly increased the number of neuronal progenitors and mature neurons, without increasing astrocytes or microglia. These pro-neuronal effects of FAB were suppressed by antagonists of estrogen receptors (ERα and ERß). In addition, treatment with FAB significantly reduced cell death induced by glutamate and this was associated with reduced expression levels of pro-inflammatory (M1) microglial cytokines, including TNFα, IL1ß and IL6, which are associated with neurotoxicity, and increased expression of IL10 and Arginase 1, which are associated with anti-inflammatory (M2) neuroprotective microglia. We also observed that FAB increased neuroprotective trophic factors, such as BDNF, NGF, NT4 and GDNF. The neuroprotective effects of FAB were also associated with increased expression of glutamate regulatory proteins in astrocytes, namely glutamine synthetase (GS) and Excitatory Amino Acid Transporter 1 (EAAT1). These findings indicate that FAB acting via estrogen signaling stimulates production of neurons in vitro and enhances the neuroprotective properties of microglia and astrocytes to significantly ameliorate glutamate-mediated neurotoxicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Glutâmico / Biflavonoides / Neurogênese / Fabaceae / Degeneração Neural Limite: Animals Idioma: En Revista: Neurotoxicology Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Glutâmico / Biflavonoides / Neurogênese / Fabaceae / Degeneração Neural Limite: Animals Idioma: En Revista: Neurotoxicology Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda