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Differential Susceptibility of Germ and Leydig Cells to Cadmium-Mediated Toxicity: Impact on Testis Structure, Adiponectin Levels, and Steroidogenesis.
Cupertino, Marli C; Novaes, Rômulo D; Santos, Eliziária C; Neves, Ana C; Silva, Edson; Oliveira, Juraci A; Matta, Sérgio L P.
Afiliação
  • Cupertino MC; Department of General Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
  • Novaes RD; Institute of Biomedical Sciences, Department of Structural Biology, Federal University of Alfenas, 37130-001 Alfenas, MG, Brazil.
  • Santos EC; School of Medicine, Federal University of Jequitinhonha and Mucuri Valleys, 39100-000 Diamantina, MG, Brazil.
  • Neves AC; Department of General Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
  • Silva E; Department of Basic and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, 39100-000 Diamantina, MG, Brazil.
  • Oliveira JA; Department of General Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
  • Matta SLP; Department of General Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
Oxid Med Cell Longev ; 2017: 3405089, 2017.
Article em En | MEDLINE | ID: mdl-29422988
This study investigated the relationship between germ and Leydig cell death, testosterone, and adiponectin levels in cadmium-mediated acute toxicity. Cadmium chloride was administered in a single dose to five groups of rats: G1 (0.9% NaCl) and G2 to G5 (0.67, 0.74, 0.86, and 1.1 mg Cd/kg). After 7 days, the animals were euthanized, and the testosterone and testes were analyzed. Dose-dependent Cd accumulation in the testes was identified. At 0.86 and 1.1 mg/kg, animals exhibited marked inflammatory infiltrate and disorganization of the seminiferous epithelium. While Leydig cells were morphologically resistant to Cd toxicity, massive germ cell death and DNA oxidation and fragmentation were observed. Although numerical density of Leydig cells was unchanged, testosterone levels were significantly impaired in animals exposed to 0.86 and 1.1 mg Cd/kg, occurring in parallel with the reduction in total adiponectins and the increase in high-molecular weight adiponectin levels. Our findings indicated that Leydig and germ cells exhibit differential microstructural resistance to Cd toxicity. While germ cells are a primary target of Cd-induced toxicity, Leydig cells remain resistant to death even when exposed to high doses of Cd. Despite morphological resistance, steroidogenesis was drastically impaired by Cd exposure, an event potentially related to the imbalance in adiponectin production.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testículo / Testosterona / Cádmio / Adiponectina / Células Germinativas / Células Intersticiais do Testículo Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testículo / Testosterona / Cádmio / Adiponectina / Células Germinativas / Células Intersticiais do Testículo Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos