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Risk factors evaluation for urolithiasis among children.
Velásquez-Forero, Francisco; Esparza, Mariela; Salas, Alejandro; Medeiros, Mara; Toussaint, Georgina; Llach, Francisco.
Afiliação
  • Velásquez-Forero F; Laboratorio de Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Mexico City, Mexico. Electronic address: fcovelfor@gmail.com.
  • Esparza M; Laboratorio de Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
  • Salas A; Laboratorio de Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez; Servicio de Nefrología, Hospital General de México, Mexico City, Mexico.
  • Medeiros M; Laboratorio de Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
  • Toussaint G; Laboratorio de Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
  • Llach F; Former Director of Clinical Nephrology and Hypertension. Georgetown University Hospital, Washington, DC, USA.
Bol Med Hosp Infant Mex ; 73(4): 228-236, 2016.
Article em En | MEDLINE | ID: mdl-29421385
BACKGROUND: The prevalence of pediatric urolithiasis varies from 0.01-0.03%. Urolithiasis may be caused by anatomical, metabolic and environmental factors. Recurrence varies between 16 to 67%, and it is frequently associated with metabolic abnormalities. The objective of the present work was the identification of risk factors that promote urolithiasis in a child population. METHODS: This study included 162 children with urolithiasis and normal renal function (mean age 7.5 years). Risk factors were investigated in two stages. In the first stage, 24-hour urine, and blood samples were analyzed to assess metabolic parameters and urinary tract infection. During the second stage, the effect of calcium restriction and a calcium load on renal Ca excretion were evaluated. Data were statistically analyzed. RESULTS: Urolithiasis was observed in 0.02% of children, 50% of them with family history of urinary stones. There were multiple risk factors for urolithiasis including hypocitraturia (70%), hypomagnesuria (42%), hypercalciuria (37%; in 11/102 was by intestinal hyperabsorption, in 13/102 was unclassified. Ca resorption or renal Ca leak were not detected). We also detected alkaline urine (21%), systemic metabolic acidosis (20%), urinary infections (16%), nephrocalcinosis with urolithiasis (11%), oliguria (8%), urinary tract anomalies, hyperuricosemia and hypermagnesemia (7% each one), hypercalcemia (6%), hyperoxaluria (2%) and hypercystinuria (0.61%). CONCLUSIONS: Hypocitraturia and hypomagnesuria were the most frequent risk factors associated with urolithiasis, followed by hypercalciuria. High PTH values were excluded. Children presented two or more risk factors for urolithiasis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Bol Med Hosp Infant Mex Ano de publicação: 2016 Tipo de documento: Article País de publicação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Bol Med Hosp Infant Mex Ano de publicação: 2016 Tipo de documento: Article País de publicação: México