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Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African-Caribbean and Caucasian patients.
Figiel, Sandy; Pinault, Michelle; Domingo, Isabelle; Guimaraes, Cyrille; Guibon, Roseline; Besson, Pierre; Tavernier, Elsa; Blanchet, Pascal; Multigner, Luc; Bruyère, Franck; Haillot, Olivier; Mathieu, Romain; Vincendeau, Sebastien; Rioux-Leclercq, Nathalie; Lebdai, Souhil; Azzouzi, Abdel-Rahmene; Perrouin-Verbe, Marie-Aimee; Fournier, Georges; Doucet, Laurent; Rigaud, Jerome; Renaudin, Karine; Mahéo, Karine; Fromont, Gaëlle.
Afiliação
  • Figiel S; Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France.
  • Pinault M; Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France.
  • Domingo I; Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France.
  • Guimaraes C; Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France.
  • Guibon R; Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France; CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France.
  • Besson P; Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France.
  • Tavernier E; CHRU Tours, Clinical Investigation Center - INSERM 1415, Tours, France.
  • Blanchet P; CHU Pointe à Pitre, Department of Urology, Guadeloupe, France; Inserm UMR1085 - IRSET, Rennes, France.
  • Multigner L; Inserm UMR1085 - IRSET, Rennes, France.
  • Bruyère F; CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France.
  • Haillot O; CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France.
  • Mathieu R; CHU Rennes, Department of Pathology, Rennes, France; CHU Rennes, Department of Urology, Rennes, France.
  • Vincendeau S; CHU Rennes, Department of Pathology, Rennes, France; CHU Rennes, Department of Urology, Rennes, France.
  • Rioux-Leclercq N; CHU Rennes, Department of Pathology, Rennes, France; CHU Rennes, Department of Urology, Rennes, France.
  • Lebdai S; CHU Angers, Department of Urology, Angers, France.
  • Azzouzi AR; CHU Angers, Department of Urology, Angers, France.
  • Perrouin-Verbe MA; CHU Brest, Department of Pathology, Brest, France; CHU Brest, Department of Urology, Brest, France.
  • Fournier G; CHU Brest, Department of Pathology, Brest, France; CHU Brest, Department of Urology, Brest, France.
  • Doucet L; CHU Brest, Department of Pathology, Brest, France; CHU Brest, Department of Urology, Brest, France.
  • Rigaud J; CHU Nantes, Department of Pathology, Nantes, France; CHU Nantes, Department of Urology, Nantes, France.
  • Renaudin K; CHU Nantes, Department of Pathology, Nantes, France; CHU Nantes, Department of Urology, Nantes, France.
  • Mahéo K; Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France.
  • Fromont G; Inserm UMR1069 "Nutrition, Croissance et Cancer" Université François Rabelais, Faculté de Médecine, 10 Bd Tonnellé, 37032 Tours, France; CHRU Bretonneau, Department of Pathology, Tours, France; CHRU Bretonneau, Department of Urology, Tours, France. Electronic address: gaelle.fromont-hankard@univ-tou
Eur J Cancer ; 91: 107-115, 2018 03.
Article em En | MEDLINE | ID: mdl-29413967
BACKGROUND: Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. METHODS: From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3). The effect of FA extracted from PPAT on in-vitro migration of PCa cells DU145 was studied in 72 patients, 36 Caucasians, and 36 African-Caribbeans. RESULTS: FA composition differed according to the ethno-geographical origin. Linoleic acid, an essential n-6 FA, was 2-fold higher in African-Caribbeans compared with Caucasian patients, regardless of disease aggressiveness. In African-Caribbeans, the FA profile associated with PCa aggressiveness was characterised by low level of linoleic acid along with high levels of saturates. In Caucasians, a weak and negative association was observed between eicosapentaenoic acid level (an n-3 FA) and disease aggressiveness. In-vitro migration of PCa cells using PPAT from African-Caribbean patients was associated with lower content of linoleic acid. CONCLUSION: These results highlight an important ethno-geographical variation of PPAT, in both their FA content and association with tumour aggressiveness.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Movimento Celular / Tecido Adiposo / População Negra / População Branca / Ácidos Graxos Tipo de estudo: Clinical_trials / Observational_studies Limite: Aged / Humans / Male / Middle aged País/Região como assunto: Caribe / Europa Idioma: En Revista: Eur J Cancer Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Movimento Celular / Tecido Adiposo / População Negra / População Branca / Ácidos Graxos Tipo de estudo: Clinical_trials / Observational_studies Limite: Aged / Humans / Male / Middle aged País/Região como assunto: Caribe / Europa Idioma: En Revista: Eur J Cancer Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido