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Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats.
Missassi, Gabriela; Dos Santos Borges, Cibele; de Lima Rosa, Josiane; Villela E Silva, Patrícia; da Cunha Martins, Airton; Barbosa, Fernando; De Grava Kempinas, Wilma.
Afiliação
  • Missassi G; Department of Morphology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
  • Dos Santos Borges C; Graduate Program in Cell and Structural Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
  • de Lima Rosa J; Department of Morphology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
  • Villela E Silva P; Department of Morphology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
  • da Cunha Martins A; Department of Morphology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, SP, Brazil.
  • Barbosa F; Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • De Grava Kempinas W; Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Oxid Med Cell Longev ; 2017: 2172981, 2017.
Article em En | MEDLINE | ID: mdl-29410731
Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Motilidade dos Espermatozoides / Varicocele / Flavonoides / Estresse Oxidativo / Infertilidade Masculina Limite: Animals / Female / Humans / Male Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Motilidade dos Espermatozoides / Varicocele / Flavonoides / Estresse Oxidativo / Infertilidade Masculina Limite: Animals / Female / Humans / Male Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos