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Development of a clinical prediction rule for the diagnosis of pleural tuberculosis in Peru.
Solari, Lely; Soto, Alonso; Van der Stuyft, Patrick.
Afiliação
  • Solari L; Unit of General Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium; Instituto Nacional de Salud, Lima, Peru. Electronic address: lsolari@ins.gob.pe.
  • Soto A; Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Chorrillos, Lima, Peru; Departamento de Medicina, Hospital Nacional Hipolito Unanue, Lima, Peru. Electronic address: pcmeasot@upc.edu.pe.
  • Van der Stuyft P; Unit of General Epidemiology and Disease Control, Institute of Tropical Medicine, Antwerp, Belgium; Department of Public Health, Ghent University, Ghent, Belgium. Electronic address: Patrick.VanDerStuyft@UGent.be.
Int J Infect Dis ; 69: 103-107, 2018 Apr.
Article em En | MEDLINE | ID: mdl-29408477
OBJECTIVES: To develop a clinical prediction rule (CPR) for the diagnosis of pleural tuberculosis (PT) in patients with pleural exudates in Peru. METHODS: Clinical and laboratory information was collected from patients with exudative pleural effusion attending two reference hospitals in Lima, Peru. Predictive findings associated with PT in a multiple logistic regression model were used to develop the CPR. A definite diagnosis of PT was based on a composite reference standard including bacteriological and/or histological analysis of pleural fluid and pleural biopsy specimens. RESULTS: A total of 238 patients were included in the analysis, of whom 176 had PT. Age, sex, previous contact with a TB patient, presence of lymphadenopathy, and pleural adenosine deaminase (ADA) levels were found to be independently associated with PT. These predictive findings were used to construct a CPR, for which the area under the receiver operating characteristics curve (AUC) was 0.92. The single best cut-off point was a score of ≥60 points, which had a sensitivity of 88%, specificity of 92%, a positive likelihood ratio of 10.9, and a negative likelihood ratio of 0.13. CONCLUSIONS: The CPR is accurate for the diagnosis of PT and could be useful for treatment initiation while avoiding pleural biopsy. A prospective evaluation is needed before its implementation in different settings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Derrame Pleural / Tuberculose Pleural / Técnicas de Apoio para a Decisão Tipo de estudo: Diagnostic_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Peru Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2018 Tipo de documento: Article País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Derrame Pleural / Tuberculose Pleural / Técnicas de Apoio para a Decisão Tipo de estudo: Diagnostic_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Peru Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2018 Tipo de documento: Article País de publicação: Canadá