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Early postnatal treatment with clomipramine induces female sexual behavior and estrous cycle impairment.
Molina-Jiménez, Tania; Limón-Morales, Ofelia; Bonilla-Jaime, Herlinda.
Afiliação
  • Molina-Jiménez T; Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-Iztapalapa, Apartado, Postal 55 535, C.P. 09340 Ciudad de México, Mexico.
  • Limón-Morales O; Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Av Universidad 3000, Cd. Universitaria, Coyoacán, 04510 Ciudad de México, Mexico.
  • Bonilla-Jaime H; Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana-Iztapalapa, Apartado Postal 55 535, C.P. 09340 Ciudad de México, Mexico. Electronic address: bjh@xanum.uam.mx.
Pharmacol Biochem Behav ; 166: 27-34, 2018 03.
Article em En | MEDLINE | ID: mdl-29407872
Administration of clomipramine (CMI), a tricyclic antidepressant, in early stages of development in rats, is considered an animal model for the study of depression. This pharmacological manipulation has induced behavioral and physiological alterations, i.e., less pleasure-seeking behaviors, despair, hyperactivity, cognitive dysfunction, alterations in neurotransmitter systems and in HPA axis. These abnormalities in adult male rats are similar to the symptoms observed in major depressive disorders. One of the main pleasure-seeking behaviors affected in male rats treated with CMI is sexual behavior. However, to date, no effects of early postnatal CMI treatment have been reported on female reproductive cyclicity and sexual behavior. Therefore, we explored CMI administration in early life (8-21 PN) on the estrous cycle and sexual behavior of adult female rats. Compared to the rats in the early postnatal saline treatment (CTRL group), the CMI rats had fewer estrous cycles, fewer days in the estrous stage, and longer cycles during a 20-day period of vaginal cytology analysis. On the behavioral test, the CMI rats displayed fewer proceptive behaviors (hopping, darting) and had lower lordosis quotients. Also, they usually failed to display lordosis and only rarely manifested marginal or normal lordosis. In contrast, the CTRL rats tended to display normal lordosis. These results suggest that early postnatal CMI treatment caused long-term disruptions of the estrous cycle and female sexual behavior, perhaps by alteration in the hypothalamic-pituitary-gonadal (HPG) axes and in neuronal circuits involved in the regulation of the performance and motivational of sexual behavior as the noradrenergic and serotonergic systems.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Sexual Animal / Clomipramina / Inibidores Seletivos de Recaptação de Serotonina / Ciclo Estral Limite: Animals / Pregnancy Idioma: En Revista: Pharmacol Biochem Behav Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Sexual Animal / Clomipramina / Inibidores Seletivos de Recaptação de Serotonina / Ciclo Estral Limite: Animals / Pregnancy Idioma: En Revista: Pharmacol Biochem Behav Ano de publicação: 2018 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos