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Cerebral injuries associated with Zika virus in utero exposure in children without birth defects in French Guiana: Case report.
Felix, Arthur; Hallet, Edouard; Favre, Anne; Kom-Tchameni, Rémi; Defo, Antoine; Fléchelles, Olivier; Rosenthal, Jean-Marc; Douine, Maylis; Nacher, Mathieu; Elenga, Narcisse.
Afiliação
  • Felix A; Department of Pediatrics, Andrée Rosemon Hospital Centre d'Investigation Clinique Antilles Guyane CIC INSERM 1424 Department of Neonatal Pediatrics and Intensive Care, Andrée Rosemon Hospital, Cayenne, French Guiana Pediatric and Neonatal Intensive Care Unit, MFME Hospital, Fort de France, Martinique Neonatal Intensive Care, Pointe à Pitre Hospital, Pointe à Pitre, Guadeloupe, France.
Medicine (Baltimore) ; 96(51): e9178, 2017 Dec.
Article em En | MEDLINE | ID: mdl-29390455
RATIONALE: A major epidemic of Zika virus (ZIKV) infection occurred in French Guiana and West Indies. French national epidemiological surveillance estimated that 1650 pregnant women contracted the ZIKV during epidemic period from January 2016 to October 2016 in French Guiana. PATIENT CONCERNS: ZIKV infection during pregnancy is a cause of microcephaly and birth defects. DIAGNOSES: In this report, we describe 2 children with proven in utero ZIKV exposure. Their mothers were both symptomatic and ZIKV infection occurred early in pregnancy. Ultrasonography monitoring in utero did not show any abnormality for both patient. They were born at full-term, healthy, without any birth defects and no sign of congenital ZIKV infection. INTERVENTIONS: ZIKV was neither found on placenta fragments nor children blood and urine at birth. Their neurodevelopment outcomes in early-life fitted the expectations. As recommended in national guidelines, we performed cerebral MRIs at 2 months old, showing severe brain abnormalities, especially of white matter areas. After a large screening, we did not find any differential diagnosis for their brain lesions. OUTCOMES: We concluded it was due to their in utero ZIKV exposure. LESSONS: In this report, pathogenicity of ZIKV may involve mother's immunological response or metabolic disorder during the infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Efeitos Tardios da Exposição Pré-Natal / Lesões Encefálicas / Imageamento por Ressonância Magnética / Infecção por Zika virus Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Male / Newborn / Pregnancy País/Região como assunto: America do sul / Caribe ingles / Guyana / Guyana francesa Idioma: En Revista: Medicine (Baltimore) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Efeitos Tardios da Exposição Pré-Natal / Lesões Encefálicas / Imageamento por Ressonância Magnética / Infecção por Zika virus Tipo de estudo: Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Infant / Male / Newborn / Pregnancy País/Região como assunto: America do sul / Caribe ingles / Guyana / Guyana francesa Idioma: En Revista: Medicine (Baltimore) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França País de publicação: Estados Unidos