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Macular and Multifocal PERG and FD-OCT in Preperimetric and Hemifield Loss Glaucoma.
Kreuz, André C; de Moraes, Carlos G; Hatanaka, Marcelo; Oyamada, Maria K; Monteiro, Mario L R.
Afiliação
  • Kreuz AC; Department of Ophthalmology and Otolaryngology, University of São Paulo Medical School (USP), São Paulo, Brazil.
  • de Moraes CG; Department of Ophthalmology, Columbia University Medical Center, New York, NY.
  • Hatanaka M; Department of Ophthalmology and Otolaryngology, University of São Paulo Medical School (USP), São Paulo, Brazil.
  • Oyamada MK; Department of Ophthalmology and Otolaryngology, University of São Paulo Medical School (USP), São Paulo, Brazil.
  • Monteiro MLR; Department of Ophthalmology and Otolaryngology, University of São Paulo Medical School (USP), São Paulo, Brazil.
J Glaucoma ; 27(2): 121-132, 2018 02.
Article em En | MEDLINE | ID: mdl-29329137
PURPOSE: To evaluate the ability of macular and multifocal (mf) pattern electroretinogram (PERG) to differentiate preperimetric glaucoma (PG) and glaucoma with hemifield loss (GHL) from controls, to compare the discrimination ability of PERG and fourier-domain optical coherence tomography (FD-OCT), and to assess the relationship between measurements. PATIENTS AND METHODS: Standard automated perimetry, steady-state and transient PERG and mfPERG measurements were obtained from PG (n=14, 24 eyes), GHL (n=5, 7 eyes), and controls (n=19, 22 eyes). Circumpapillary retinal nerve fiber layer (cpRNFL), full-thickness macula, and segmented macular layer thicknesses on FD-OCT were investigated. Measurements were compared using mixed effects linear models. The relationships between measurements and the diagnostic performance of each technology were assessed. RESULTS: Compared with controls, average P50 peak time transient PERG responses were reduced in PG and GHL, whereas average latency and amplitude steady-state and mfPERG responses were abnormal only in GHL. cpRNFL and macular thickness measurements in PG and GHL differed significantly from controls. A significant relationship was found between PERG and most FD-OCT or SAP parameters. Partial least squares discriminant analysis revealed that OCT parameters, along with mfPERG and transient PERG parameters had similar ability to discriminate PG and GHL from healthy controls. CONCLUSIONS: PERG and OCT parameters may be abnormal, with significant correlations between measurements, in PG eyes. Both technologies may be useful for detection of early glaucoma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Campos Visuais / Glaucoma de Ângulo Aberto / Hemianopsia / Tomografia de Coerência Óptica / Eletrorretinografia Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: J Glaucoma Assunto da revista: OFTALMOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Campos Visuais / Glaucoma de Ângulo Aberto / Hemianopsia / Tomografia de Coerência Óptica / Eletrorretinografia Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: J Glaucoma Assunto da revista: OFTALMOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos