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Ivermectin acute administration impaired the spermatogenesis and spermiogenesis of adult rats.
Cordeiro, Flora; Gonçalves, Vagner; Moreira, Natalia; Slobodticov, João Iosif; de Andrade Galvão, Nathalia; de Souza Spinosa, Helenice; Bonamin, Leoni Villano; Bondan, Eduardo Fernandes; Ciscato, Claudia Helena Pastor; Barbosa, Cláudia Maria; Bernardi, Maria Martha.
Afiliação
  • Cordeiro F; Graduate Program of Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 1212, 04026-002 São Paulo, SP, Brazil.
  • Gonçalves V; Graduate Program of Experimental and Comparative Pathology, Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, São Paulo, SP 05508-270, Brazil.
  • Moreira N; Graduate Program of Experimental and Comparative Pathology, Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, São Paulo, SP 05508-270, Brazil.
  • Slobodticov JI; Graduate Program of Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 1212, 04026-002 São Paulo, SP, Brazil.
  • de Andrade Galvão N; Graduate Program of Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 1212, 04026-002 São Paulo, SP, Brazil.
  • de Souza Spinosa H; Graduate Program of Experimental and Comparative Pathology, Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, São Paulo, SP 05508-270, Brazil.
  • Bonamin LV; Graduate Program of Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 1212, 04026-002 São Paulo, SP, Brazil.
  • Bondan EF; Graduate Program of Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 1212, 04026-002 São Paulo, SP, Brazil.
  • Ciscato CHP; Pesticide Residues Laboratory, Biological Institute, Av. Conselheiro Rodrigues Alves, 1252, São Paulo, SP 04014-002, Brazil.
  • Barbosa CM; Pesticide Residues Laboratory, Biological Institute, Av. Conselheiro Rodrigues Alves, 1252, São Paulo, SP 04014-002, Brazil.
  • Bernardi MM; Graduate Program of Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 1212, 04026-002 São Paulo, SP, Brazil. Electronic address: maria.bernardi@docente.unip.br.
Res Vet Sci ; 117: 178-186, 2018 Apr.
Article em En | MEDLINE | ID: mdl-29288959
Ivermectin (IVM) is an antiparasitic agent widely used in agricultural, domestic animals and in human clinical practice. In the present study, the temporal effects of therapeutic doses of IVM in the morphometric and histological assessment of testis were studied to verify if IVM acute administration impaired the spermatogenesis and spermiogenesis of adult rats, if these effects are reversible. The testosterone levels and the plasmatic IVM levels were assessed. The results show: 1) IVM acute exposure, mainly in the higher dose, reduced the testicular volume, the tubular diameter and the germinal epithelium height; 2) no interferences on Leydig cells frequency; 3) histological studies show that tubular sections containing several histological changes indicative of spermatogenesis interruption, such as disorganization of germinal epithelium, vacuolar degeneration of the germ cells and sloughing of cells into the tubular lumen; 4) no differences in testosterone levels; 5) The IVM plasmatic levels were significantly reduced at 72h after the 0.2mg/kg. It was concluded that acute IVM impaired the spermatogenesis and spermiogenesis of rats. Probably these effects were not consequence of IVM at the Leydig cells because no effects were observed at this level. Finally, our results suggest that some testicular effects are reversible and correlated with the plasmatic levels of IVM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espermatogênese / Ivermectina Limite: Adult / Animals / Humans / Male Idioma: En Revista: Res Vet Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espermatogênese / Ivermectina Limite: Adult / Animals / Humans / Male Idioma: En Revista: Res Vet Sci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido