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Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice.
Ramírez-Espinosa, Juan José; Saldaña-Ríos, Johann; García-Jiménez, Sara; Villalobos-Molina, Rafael; Ávila-Villarreal, Gabriela; Rodríguez-Ocampo, Angélica Nallelhy; Bernal-Fernández, Germán; Estrada-Soto, Samuel.
Afiliação
  • Ramírez-Espinosa JJ; Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Juárez 32310, Chihuahua, Mexico. jjre9785@gmail.com.
  • Saldaña-Ríos J; Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico.
  • García-Jiménez S; Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico. srje_ff@uaem.mx.
  • Villalobos-Molina R; UBIMED, FES-Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Estado de México, Mexico. villalobos@campus.iztacala.unam.mx.
  • Ávila-Villarreal G; Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, Universidad Autónoma de Nayarit, Tepic 63000, Nayarit, Mexico. saragarcia@uaem.mx.
  • Rodríguez-Ocampo AN; Centro Nayarita de Innovación y Transferencia de Tecnología "Unidad especializada en I+D+i en Calidad de Alimentos y Productos Naturales", Universidad Autónoma de Nayarit, Tepic 63173, Nayarit, Mexico. saragarcia@uaem.mx.
  • Bernal-Fernández G; Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, Universidad Autónoma de Nayarit, Tepic 63000, Nayarit, Mexico. angelica.rodriguez@uan.edu.mx.
  • Estrada-Soto S; Centro Nayarita de Innovación y Transferencia de Tecnología "Unidad especializada en I+D+i en Calidad de Alimentos y Productos Naturales", Universidad Autónoma de Nayarit, Tepic 63173, Nayarit, Mexico. angelica.rodriguez@uan.edu.mx.
Molecules ; 23(1)2017 Dec 28.
Article em En | MEDLINE | ID: mdl-29283418
Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory and antidiabetic effects, among others. Thus, a diabetic model in athymic nude mice was developed and used to establish the ability of chrysin to decrease the secretion of pro-inflammatory cytokines. Also, it was determined the acute (50 mg/kg) and sub-acute (50 mg/kg/day/10 days) antidiabetic and antihyperlipidemic activities after the period of time treatment. Results indicate that chrysin has significant acute antihyperglycemic and antidiabetic effects in nude diabetic mice (p < 0.05). Moreover, triglyceride blood levels were reduced and IL-1ß and TNF-α were diminished after 10 days' treatment compared with control group (p < 0.05). In conclusion, it was found that chrysin could produce similar effects as metformin, a drug used for the treatment of diabetes, since both test samples decreased glucose and triglycerides levels, they impaired the generation of pro-inflammatory cytokines involved in the development of diabetes and its consequences, such as atherosclerosis and other cardiovascular diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Diabetes Mellitus Experimental / Hipoglicemiantes / Anti-Inflamatórios / Hipolipemiantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Flavonoides / Diabetes Mellitus Experimental / Hipoglicemiantes / Anti-Inflamatórios / Hipolipemiantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Suíça