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Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol.
Jentzsch, Nulma S; Silva, Gabriela C G; Mendes, Guilherme M S; Brand, Paul L P; Camargos, Paulo.
Afiliação
  • Jentzsch NS; Faculdade de Ciências Médicas de Minas Gerais, Hospital Universitário Ciências Médicas, Belo Horizonte, MG, Brazil. Electronic address: nulma.jentzsch@cienciasmedicasmg.edu.br.
  • Silva GCG; Faculdade de Ciências Médicas de Minas Gerais, Hospital Universitário Ciências Médicas, Belo Horizonte, MG, Brazil.
  • Mendes GMS; Faculdade de Ciências Médicas de Minas Gerais, Hospital Universitário Ciências Médicas, Belo Horizonte, MG, Brazil.
  • Brand PLP; Isala Hospital, Princess Amalia Children's Centre, Zwolle, The Netherlands; University Medical Centre and University of Groningen, UMCG Postgraduate School of Medicine, Groningen, The Netherlands.
  • Camargos P; Universidade Federal de Minas Gerais (UFMG), Hospital das Clínicas, Unidade de Pneumologia Pediátrica, Belo Horizonte, MG, Brazil.
J Pediatr (Rio J) ; 95(1): 69-75, 2019.
Article em En | MEDLINE | ID: mdl-29274305
OBJECTIVE: There is a scarcity of studies that assessed the association between adherence to combination therapy and asthma control in pediatric patients. The authors investigated the association between adherence to fluticasone propionate/salmeterol xinafoate combination-metered aerosol and the level of asthma control in children. METHODS: This was a prospective observational study of 84 patients aged 5-16 years with moderate persistent asthma, who remained uncontrolled despite the use of 1000µg/day of inhaled nonextrafine-hydrofluoric alkane-beclomethasone dipropionate in the three months prior to study enrollment. Participants were prescribed two daily doses of FP (125µg)/salmeterol xinafoate (25µg) combination by metered aerosol/spacer for six months. Adherence rates were assessed using the device's dose counter after the 2nd, 4th, and 6th months of follow up. Asthma control was assessed using a simplified Global Initiative for Asthma 2014 Report classification. RESULTS: Mean adherence rates after the second, fourth, and sixth months were 87.8%, 74.9%, and 62.1% respectively, for controlled asthma, and 71.7%, 56.0%, and 47.6% respectively, for uncontrolled asthma (all p-values≤0.03). The proportion of children achieving asthma control increased to 42.9%, 67.9% and 89.3% after the 2nd, 4th and 6th months of follow-up, respectively (p≤0.001). CONCLUSION: Adherence rates between 87.8% in the 2nd month and 62.1% in the 6th month were strong determinants of asthma control.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Broncodilatadores / Xinafoato de Salmeterol / Fluticasona / Cooperação e Adesão ao Tratamento Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2019 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Broncodilatadores / Xinafoato de Salmeterol / Fluticasona / Cooperação e Adesão ao Tratamento Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2019 Tipo de documento: Article País de publicação: Brasil