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Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90.
Mazaira, Gisela I; Daneri-Becerra, Cristina; Zgajnar, Nadia R; Lotufo, Cecilia M; Galigniana, Mario D.
Afiliação
  • Mazaira GI; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Daneri-Becerra C; Instituto de Biología y Medicina Experimental (IBYME)-CONICET, Buenos Aires 1428, Argentina.
  • Zgajnar NR; Instituto de Biología y Medicina Experimental (IBYME)-CONICET, Buenos Aires 1428, Argentina.
  • Lotufo CM; Instituto de Biología y Medicina Experimental (IBYME)-CONICET, Buenos Aires 1428, Argentina.
  • Galigniana MD; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires, Buenos Aires, Argentina mgaligniana@conicet.gov.ar.
Biochem Soc Trans ; 46(1): 51-65, 2018 02 19.
Article em En | MEDLINE | ID: mdl-29273620
The ability to permit gene expression is managed by a set of relatively well known regulatory mechanisms. Nonetheless, this property can also be acquired during a life span as a consequence of environmental stimuli. Interestingly, some acquired information can be passed to the next generation of individuals without modifying gene information, but instead by the manner in which cells read and process such information. Molecular chaperones are classically related to the proper preservation of protein folding and anti-aggregation properties, but one of them, heat-shock protein 90 (Hsp90), is a refined sensor of protein function facilitating the biological activity of properly folded client proteins that already have a preserved tertiary structure. Interestingly, Hsp90 can also function as a critical switch able to regulate biological responses due to its association with key client proteins such as histone deacetylases or DNA methylases. Thus, a growing amount of evidence has connected the action of Hsp90 to post-translational modifications of soluble nuclear factors, DNA, and histones, which epigenetically affect gene expression upon the onset of an unfriendly environment. This response is commanded by the activation of the transcription factor heat-shock factor 1 (HSF1). Even though numerous stresses of diverse nature are known to trigger the stress response by activation of HSF1, it is still unknown whether there are different types of molecular sensors for each type of stimulus. In the present review, we will discuss various aspects of the regulatory action of HSF1 and Hsp90 on transcriptional regulation, and how this regulation may affect genetic assimilation mechanisms and the health of individuals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Proteínas de Choque Térmico HSP90 / Fatores de Transcrição de Choque Térmico Limite: Animals / Humans Idioma: En Revista: Biochem Soc Trans Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Proteínas de Choque Térmico HSP90 / Fatores de Transcrição de Choque Térmico Limite: Animals / Humans Idioma: En Revista: Biochem Soc Trans Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido